Modular Biochip Substrate With Observation Ports and Fixing Elements
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Solution Overview
Problem
Existing biochips face challenges in widespread application due to dense distribution, manufacturing difficulties, high costs, and the need for specialized instruments for preservation and analysis, while lacking cost-effectiveness and flexibility.
Innovation Solution
A method involving the manufacturing of a substrate with observation ports and fixing elements to secure reaction chips, allowing for flexible arrangement of different types of reaction components on a single substrate, using deformable fixing elements like L-shaped columns or cones to fix reaction chips in place.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If reaction chips are densely distributed on substrate to enhance analysis accuracy and reduce sample amounts, then analysis precision and sample efficiency are improved, but manufacturing difficulty and cost increase
Solution Approach 1:
The substrate is divided into multiple independent reaction chips, each capable of performing separate biochemical reactions. This segmentation allows for standardized manufacturing of individual chips while maintaining high density on the substrate, resolving the contradiction between analysis precision and manufacturing difficulty
Solution Approach 2:
The substrate serves multiple functions: it provides structural support, contains observation ports for detection, and integrates multiple fixing elements for securing reaction chips. This multi-functionality reduces the need for additional components, simplifying manufacturing while maintaining high reaction density
2Reliability
If specialized instruments are used for preservation and analysis of biochips, then measurement precision and reliability are improved, but device complexity and cost increase
Solution Approach 1:
The substrate acts as an intermediary platform that integrates both reaction and detection functions. By incorporating observation ports directly into the substrate, the system eliminates the need for complex external instrumentation, reducing device complexity while maintaining analysis reliability
Solution Approach 2:
The patent merges the reaction chamber and detection window into a single integrated structure. The observation ports are formed directly through the substrate, combining the functions of reaction containment and optical access, thereby simplifying the overall device while ensuring reliable analysis
3Manufacturing precision
If fixed manufacturing methods are used for biochips, then manufacturing precision is maintained, but adaptability and flexibility for different reaction types are reduced
Solution Approach 1:
The substrate is pre-formed with standardized observation ports and fixing element positions before reaction chips are attached. This preliminary structuring ensures manufacturing precision while allowing different reaction chips to be freely configured on the standardized platform, enhancing adaptability
Solution Approach 2:
Different regions of the substrate can accommodate different types of reaction chips with specific functionalities. Each local area maintains standardized fixing mechanisms for precision, while the variety of reaction chip types provides flexibility for different biochemical applications
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method enables cost-effective biochip production with enhanced flexibility and reduced costs, facilitating easy customization and integration of various reactions on a single biochip, while maintaining accuracy and integrity of analysis results.
Implementation Method 1
the plurality of fixing elements are heated to melt and achieve the deformation
Data Source
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AI summary
Provided is a method for manufacturing biochip, including: manufacturing a substrate; forming a plurality of observation ports that penetrate the substrate on the substrate; providing a plurality of fixing elements on a bottom surface of the substrate, each the fixing elements surrounding each of the plurality of observation ports; providing a plurality of reaction chips corresponding in position to the plurality of observation ports respectively and disposed at the bottom surface; and fixing the plurality of reaction chips in place using the plurality of fixing elements, respectively. Further provided are a biochip manufactured by the method and a testing method using the biochip.