Modular Biochip Processing Interface for Universal Sample Handling
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Solution Overview
Problem
Current biochip systems require different cartridges for various sample materials due to distinct processing needs, leading to increased production costs, complexity, and manual or semi-manual processing, which is undesirable in clinical settings.
Innovation Solution
A modular processing system that includes a processing module with a hollow space and interface for connecting to a miniaturized laboratory cartridge, allowing for different processing steps such as concentration, extraction, and amplification, using magnetic beads and mechanical elements to adapt to various sample types, enabling a universal cartridge for multiple sample materials.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If different cartridges are developed for different sample materials, then the processing can be optimized for each sample type, but the production costs and device complexity increase
Solution Approach 1:
The patent implements a universal cartridge design that can process multiple sample types (blood, sputum, biopsies, urine) through a standardized interface and integrated sample processing chamber. The cartridge incorporates universal reagent reservoirs and a standardized microfluidic pathway that adapts to different sample materials without requiring separate cartridge designs for each sample type.
Solution Approach 2:
The patent segments the sample processing function into a separate modular sample processing device that interfaces with the universal cartridge. This allows the cartridge to remain simple and standardized while the external processing device handles sample-specific preprocessing steps, effectively separating the universal analysis function from the variable sample preparation function.
2Adaptability or versatility
If manual or semi-manual processing is used for different sample materials, then the processing can be customized, but the reproducibility and risk of infection increase
Solution Approach 1:
The patent implements automated sample processing where the system automatically performs sample intake, reagent mixing, and processing steps through integrated pumps and valves. The standardized protocol is automatically executed for different sample types, eliminating manual intervention and ensuring consistent, reproducible processing while reducing infection risk through closed-system automation.
Solution Approach 2:
The patent incorporates dynamic control elements including programmable pumps, temperature-controlled chambers, and automated valve systems that adapt processing parameters based on the selected sample type. The system can dynamically adjust processing conditions while maintaining automated operation, ensuring both versatility and reproducibility.
3Measurement precision
If larger quantities of sample material are processed to increase pathogen concentration, then the detection sensitivity improves, but the cartridge size increases beyond check card format
Solution Approach 1:
The patent employs nested microfluidic channels and integrated reagent reservoirs within the cartridge structure, allowing efficient use of space. The design incorporates multiple functional elements nested within each other, enabling the processing of larger sample volumes while maintaining a compact check card format through three-dimensional spatial optimization.
Solution Approach 2:
The patent uses microfluidic hydraulic principles to efficiently transport and concentrate sample materials through the cartridge. Integrated pumps and pressure control systems enable the processing of larger sample volumes by creating controlled fluid flow paths that concentrate pathogens within the compact cartridge structure, maintaining detection sensitivity without increasing external dimensions.
Data Source
AI summary
A module for processing a biological sample for an analysis test is disclosed. The processing module includes, in at least one embodiment, an interface at which the processing module can be connected to a cartridge with a lab-on-a-chip, in which cartridge the analysis steps are carried out. A biochip kit is also disclosed. In at least one embodiment, the biochip kit includes one or more processing modules which are intended for different sample materials and which can be connected to the same cartridge type.