Modular Coaxial Bioprinting Nozzle for Layer Alignment and Cleaning
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Solution Overview
Problem
Existing bioprinting nozzles face challenges in adaptability for multiple layers, centering and alignment, temperature control, internal pressure management, and ease of assembly and cleaning, particularly when handling sensitive biomaterials.
Innovation Solution
A modular nozzle design with multiple modules that can be assembled and disassembled by users, featuring coaxial alignment, temperature control through insulating enclosures and fluid circulation, and pressure regulation, allowing for customizable layering and sterile conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a fixed multi-layer nozzle design is used, then the nozzle can print multiple layers simultaneously, but the adaptability for different numbers of layers is limited
Solution Approach 1:
The nozzle is divided into multiple separate modules, each capable of being independently attached or detached. This segmentation allows the user to configure the nozzle for different numbers of layers by selectively assembling the required modules, thereby achieving adaptability without requiring a completely different nozzle design for each layer configuration.
Solution Approach 2:
The nozzle transitions from a static, fixed configuration to a dynamic, reconfigurable structure. The modules can be dynamically assembled and disassembled based on the specific printing requirements, enabling the nozzle to adapt to different numbers of layers while maintaining a relatively simple base structure.
2Ease of operation
If a modular design is used, then the nozzle is easier to assemble and clean, but the centering and alignment precision may be compromised
Solution Approach 1:
The modules incorporate self-centering and self-aligning features that automatically ensure precise coaxial alignment when the modules are assembled. This self-service mechanism eliminates the need for complex external alignment tools or procedures, allowing users to easily assemble the modules while maintaining high precision without requiring specialized skills or equipment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables adaptable, high-viability bioprinting of complex tubular structures with precise layer control and temperature management, suitable for sensitive biomaterials, enhancing the quality of bioprinted constructs.
Implementation Method 1
temperature control through insulating enclosures and fluid circulation
Implementation Method 2
temperature control through insulating enclosures and fluid circulation
Data Source
Figure 1a~1b
Figure 2a~2b
Figure 3
AI summary
The present invention relates to a nozzle (30) for coaxial extrusion¬ based bioprinting comprising multiple separate modules comprising an inlet (12), an extrusion channel and an outlet. The modules are adapted to be assembled and reassembled and are configured such that the extrusion channels are essentially coaxially and concentrically aligned along the longitudinal axis of a first module when forming a nozzle.