Modular Bioreactor Chamber with Detachable Sealed Sections
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Solution Overview
Problem
Current bioreactor chambers are inflexible in size, making it costly and inconvenient to adjust volume according to cell culture medium or cell culture quantity, and they lack easy observation of cell growth and fixed fluid direction.
Innovation Solution
An assembled bioreactor chamber with detachable and modular components that allow for adjustable volume by connecting upper, intermediate, and lower portions through a sealed mechanism, enabling flexible configuration and observation of cell growth, with optional barrier sheets for fluid flow manipulation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a fixed-size bioreactor chamber is used, then the structure is simple and easy to manufacture, but the volume cannot be adjusted according to cell culture medium or cell culture quantity
Solution Approach 1:
The bioreactor chamber is divided into multiple detachable portions (first portion, second portion, third portion) that can be connected in different combinations. Each portion has standardized connection interfaces that enable flexible assembly to achieve different volumes while maintaining structural integrity and sealing.
2Adaptability or versatility
If the bioreactor chamber is made detachable and modular, then the volume can be adjusted flexibly, but the connection mechanism becomes more complex
Solution Approach 1:
The connection interface is designed as a universal standardized structure that serves multiple functions: mechanical connection, sealing, and alignment. This universal interface can be used for connecting any two portions (first-second, second-third, or any combination), simplifying the manufacturing process while enabling flexible volume adjustment.
3Adaptability or versatility
If the chamber is assembled from multiple portions, then the volume can be increased or decreased as desired, but the sealing between portions becomes more difficult to ensure
Solution Approach 1:
A sealing element (such as an O-ring or gasket) is introduced as an intermediary component between the connection portions. This sealing element is compressed by the connection mechanism to create a reliable seal, preventing leakage while allowing the portions to be detached and reconfigured.
4Adaptability or versatility
If a fixed fluid direction is designed in the reactor chamber, then the fluid flow path is simple, but the fluid direction cannot be changed according to different culture needs
Solution Approach 1:
The fluid flow direction is made dynamic and adjustable by incorporating flow control elements (such as valves or redirectors) at the connection interfaces between portions. These elements can be configured to direct fluid flow in different directions (e.g., upward or downward) depending on the cultural needs, while maintaining a relatively simple overall structure.
Data Source
AI summary
Provided is an assembled bioreactor chamber comprising an upper end portion, at least one intermediate portion and a lower end portion for forming a chamber of the reactor chamber. The upper end portion and the lower end portion are respectively provided with an interface connected with a culture medium line, and the upper end portion and the intermediate portion, and the intermediate portion and the lower end portion are detachably connected in a sealed manner through a connecting mechanism; when the number of the intermediate portions is ≥2, the adjacent intermediate portions are detachably connected in a sealed manner through a connecting mechanism; and the chamber also comprises a cell carrier for cell attachment growth.