Modular Multi-Assay Device for Point-of-Care Diagnostics
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Solution Overview
Problem
Current clinical testing methods are hindered by human errors, time-consuming processes, limited accessibility, and inefficiencies in sample collection and analysis, leading to delayed diagnosis and inadequate medical responses, particularly for time-sensitive conditions and chronic disease management.
Innovation Solution
A modular system comprising sample preparation, assay, and detection stations configured to perform various laboratory procedures, including immunoassays, nucleic acid assays, and cytometric assays, capable of operating at the point of care with high accuracy and speed, utilizing fluidically isolated assay units and a control unit for computer-executable commands.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If multiple separate devices are used to perform different assays, then each assay can be performed with dedicated equipment, but the overall system complexity and space requirements increase significantly
Solution Approach 1:
The patent combines multiple separate assay devices into a single integrated device that can perform multiple different assays. The device includes multiple modules (sample preparation module, incubation module, detection module) that can handle different assay types (ELISA, Western blot, immunoprecipitation) within one unified system, reducing the number of separate devices needed while maintaining assay performance.
Solution Approach 2:
The device is designed with universal capabilities to perform multiple different assays through configurable modules. The sample preparation module can handle various sample types, the incubation module can accommodate different plate formats, and the detection module can measure multiple wavelengths, making the device versatile for different analytical needs without requiring separate specialized equipment.
2Quantity of substance
If large volumes of sample are used for multiple assays, then sufficient material is available for analysis, but sample consumption increases and may deplete limited biological samples
Solution Approach 1:
The device segments the sample processing into distinct modules where a single sample can be sequentially processed through sample preparation, incubation, and detection stages. This segmentation allows the same sample to be used for multiple different assays by dividing the processing steps across separate functional modules, thereby reducing the total sample volume required while ensuring sufficient material is available for each analytical stage.
3Reliability
If multiple separate devices are deployed for different assays, then each device can be optimized for its specific function, but the space required and operational complexity increase
Solution Approach 1:
The device employs a nested modular architecture where smaller functional modules (sample preparation, incubation, detection) are integrated within a compact hierarchical structure. Each module can be independently optimized for its specific function while being physically nested within the overall device footprint, allowing multiple assay capabilities to coexist in a space-efficient configuration that reduces the total area required compared to separate dedicated devices.
Data Source
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AI summary
Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.