Modular Pyridone Derivatives for Crop-Selective Herbicidal Activity
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing herbicides do not effectively address the need for selective and efficient weed control in agricultural and horticultural settings, particularly in crops of useful plants.
Innovation Solution
Development of novel pyridone derivatives with specific structural features, including various substituents, which exhibit enhanced herbicidal activity against weeds.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing herbicides are used, then weed control is provided, but the herbicidal activity is insufficient and selective control is not achieved
Solution Approach 1:
The patent applies local quality by introducing specific substituent patterns at defined positions on the pyridone core structure. Different substituents (R1-R6) are placed at specific locations to create localized functional regions that provide both high herbicidal activity and crop selectivity. For example, specific groups at R2, R4, and R5 positions create targeted interactions with weed enzymes while sparing crop plants.
Solution Approach 2:
The patent employs parameter changes by systematically varying the chemical structure of the pyridone derivatives through different substituent types, sizes, and electronic properties. This includes changing alkyl chain lengths, aromatic ring substitutions, and heteroatom configurations to optimize the balance between herbicidal potency and selective control, achieving enhanced activity while maintaining crop safety.
2Reliability
If novel pyridone derivatives with specific structural features are developed, then enhanced herbicidal activity is achieved, but the structural complexity increases
Solution Approach 1:
The patent applies universality by designing a core pyridone structure that serves multiple functions: the basic ring provides binding affinity, while various substituent positions (R1-R6) can be independently optimized for different properties such as solubility, metabolic stability, and target binding. This modular approach allows one core structure to generate multiple active compounds with tailored properties, reducing the need for entirely different molecular scaffolds.
Solution Approach 2:
The patent uses segmentation by dividing the herbicide molecule into distinct functional segments: the pyridone core provides the essential binding motif, while R1-R6 substituents represent separable functional modules that can be independently designed and optimized. This segmentation allows systematic structure-activity relationship studies and simplifies the design process by treating each substituent position as an independent optimization target.
Data Source
AI summary
Compounds of Formula (I) wherein the substituents are as defined in claim 1. The invention further relates to herbicidal compositions which comprise a compound of Formula (I) and to the use of compounds of Formula (I) for controlling weeds, in particular in crops of useful plants.