Modular Sample Block Tray for Compact Fluorescence Thermal Cycling
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Solution Overview
Problem
There is a need to automate biological analysis systems to increase efficiency, cater to user needs, and reduce lab space requirements while ensuring ease of installation and use.
Innovation Solution
A biological analysis system comprising a sample block assembly with a sample holder, a control system for temperature cycling, and an optical system for fluorescence detection, along with modular components that can be reversibly connected to form different device types, and a calibration system for instrument validation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If automated biological analysis systems are implemented, then efficiency and productivity are improved, but device complexity and installation difficulty increase
Solution Approach 1:
The biological analysis system is divided into separate functional modules: a sample processing module with temperature cycling capability, and a separate detection module with optical detection system. These modules can be used independently or combined, reducing overall system complexity while maintaining high productivity through automated processing.
Solution Approach 2:
The system design allows a single module to serve multiple functions - the sample block assembly can be used with different detection modules, and the tray mechanism supports various sample holder configurations. This multi-functionality reduces the need for multiple specialized devices, simplifying installation while preserving automated efficiency.
2Adaptability or versatility
If modular reversible connection design is used, then ease of installation and adaptability are improved, but device complexity increases
Solution Approach 1:
The connection between modules uses a dynamic reversible mechanism where the detection module can be easily attached to and detached from the sample processing module. This dynamic connection system allows flexible reconfiguration for different experimental needs without requiring complex permanent assemblies, balancing adaptability with manageable complexity.
3Area of stationary object
If compact design is implemented, then lab space requirements are reduced, but ease of operation and user access deteriorate
Solution Approach 1:
The system uses a vertical stacking arrangement where the detection module is positioned above the sample block, and the tray mechanism provides vertical access rather than horizontal. This three-dimensional compact design reduces the horizontal lab space footprint while maintaining easy user access through the vertically sliding tray mechanism.
4Measurement precision
If integrated optical and thermal systems are combined, then measurement precision is improved, but device complexity and manufacturing difficulty increase
Solution Approach 1:
The optical detection system and thermal cycling system are manufactured as separate modules with well-defined interfaces. The sample block assembly is manufactured independently with precise thermal characteristics, while the detection module is manufactured separately with optimized optical pathways. This segmentation enables specialized manufacturing for each module, improving overall measurement precision while simplifying the manufacturing process through modular production.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system enhances automation, user-friendly operation, and reduces space requirements while providing accurate fluorescence analysis and instrument calibration, improving overall efficiency and usability.
Implementation Method 1
an optical system configured to deliver excitation light to the plurality of samples and detect a fluorescence level emitted from each of the plurality of samples
Implementation Method 2
a heated cover comprising a lower plate, a heater, and an upper plate
Data Source
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AI summary
A biological analysis system is provided. The system comprises a sample block assembly. The sample block assembly comprises a sample block configured to accommodate a sample holder, the sample holder configured to receive a plurality of samples. The system also comprises a control system configured to cycle the plurality of samples through a series of temperatures. The system further comprises an automated tray comprising a slide assembly, the tray configured to reversibly slide the sample block assembly from a closed to an open position to allow user access to the plurality of sample holders.