Moisture-Activated Latent Curing Adhesive for Surgical Sealing
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current adhesives and sealants for surgical applications lack biocompatibility, do not mimic tissue mechanical performance, and are not suitable for internal use, failing to provide effective sealing and tissue regeneration while avoiding tissue damage and toxicity.
Innovation Solution
A moisture-activated latent curing adhesive or sealant mixture comprising a ketimine or aldimine and an amine reactive moiety, which forms a poly(ethylene oxide)imine that reacts upon exposure to moisture, creating a biocompatible and biodegradable sealant suitable for internal surgical use, with adjustable cure speed and storage stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If a latent curing adhesive is used for industrial applications, then storage stability is improved, but biocompatibility and suitability for internal use deteriorate
Solution Approach 1:
The patent modifies the chemical parameters of the curing agent by using a ketimine or aldimine structure that is stable during storage but converts to a reactive amine in the presence of moisture. This parameter change enables the adhesive to maintain stability during storage while becoming biocompatible and reactive only when needed in the surgical environment
Solution Approach 2:
The patent utilizes a chemical phase transition where the ketimine/aldimine group remains non-reactive during storage and then transitions to a reactive amine form upon exposure to moisture in the surgical site. This phase transition from latent to active state ensures both storage stability and biocompatibility during use
2Productivity
If the adhesive cures quickly, then productivity is improved, but tissue damage from exothermic process worsens
Solution Approach 1:
The patent implements a two-stage curing process where the adhesive first provides immediate tack for primary fixation, then cures gradually over time as moisture is absorbed. This periodic action allows manipulation and re-alignment initially, then progresses to strong bonding without excessive heat generation at any single moment
Solution Approach 2:
The patent creates a dynamic curing system where the cure speed is not fixed but adjusts based on moisture availability. The adhesive transitions from a mobile, manipulable state to a progressively curing state, allowing surgical manipulation initially while ensuring eventual strong bonding without uncontrolled exothermic reactions
3Strength
If the adhesive provides strong immediate fixation, then strength is improved, but opportunity for manipulation and re-alignment deteriorates
Solution Approach 1:
The patent implements a two-stage curing process where the adhesive first provides immediate tack for primary fixation, then cures gradually over time as moisture is absorbed. This periodic action allows manipulation and re-alignment initially, then progresses to strong bonding without excessive heat generation at any single moment
Solution Approach 2:
The patent provides preliminary fixation through immediate tack upon application, allowing the tissue to be held in position while still permitting manipulation and re-alignment. The strong bonding develops progressively as moisture triggers the curing reaction, ensuring both initial manipulability and eventual strong fixation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides effective sealing, biocompatibility, and adjustable cure speed, facilitating tissue regeneration with minimal scarring and eliminating harmful degradation products, suitable for various surgical procedures including cardiovascular and orthopedic surgeries.
Implementation Method 1
the latent curing agent may be converted to a reactive curing agent in the presence of moisture that is present in the environment or supplied to the site upon use. It is well known in the art, for example, that a ketimine moiety may be used as a latent curing agent that may be converted to a reactive curing agent, i.e., an amine moiety, in the presence water
Data Source
AI summary
The invention relates to a novel poly(ethylene oxide)imine; a novel amine reactive moiety; a novel moisture activated latent curing adhesive or sealant mixture comprising (1) a ketimine or aldimine, and (2) an amine reactive moiety; and a novel moisture activated latent curing adhesive or sealant comprising the reaction product of (1) and (2).