Solvent-Free Moisture-Activated Surgical Adhesive
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Solution Overview
Problem
Existing surgical adhesives and sealants face challenges in providing sufficient adhesive strength, avoiding tissue damage from exothermic reactions, non-toxicity, biodegradability, and minimal scarring, while also needing to prevent fluid leakage and be suitable for internal use without harmful solvent residues.
Innovation Solution
A solvent-free, moisture-activated latent curing adhesive or sealant mixture comprising a poly(alkylene oxide)imine and an amine reactive moiety, both in liquid form at ambient conditions, which reacts upon exposure to moisture to form a biocompatible and biodegradable adhesive, allowing for extended mixing time without premature gelling and improved tissue adhesion properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If solvent is used in latent curing adhesive formulations to maintain liquid form under ambient conditions, then the adhesive can be stored and handled easily, but harmful solvent residues may remain in the body and cause toxic responses
Solution Approach 1:
The patent removes the solvent component entirely from the adhesive formulation, extracting the harmful element while preserving the essential two-component latent curing system. The adhesive consists only of the ketimine component and the amine reactive moiety, both in neat liquid form, eliminating solvent residues that could cause toxic responses.
Solution Approach 2:
The patent changes the physical state parameters of the adhesive components by selecting specific molecular weight ranges and chemical structures that allow the ketimine and amine reactive moiety to remain liquid under ambient conditions without requiring solvent. This parameter optimization enables solvent-free formulation while maintaining operability.
2Strength
If exothermic curing process is used to achieve sufficient adhesive strength, then bonding strength is improved, but surrounding tissue may be damaged from heat generation
Solution Approach 1:
The patent employs a latent curing mechanism where the ketimine component remains non-reactive during storage and application, then activates upon exposure to moisture at the surgical site. This dynamic control allows the adhesive to transition from a stable, non-exothermic state during handling to a curing state only when needed, reducing unwanted heat generation during application.
Solution Approach 2:
The patent uses moisture (water) as an intermediary trigger to activate the curing process. The ketimine component reacts with water to generate the active amine species in situ, which then reacts with the amine reactive moiety. This intermediary mechanism provides controlled activation and moderates the exothermic process compared to direct mixing of fully reactive components.
3Strength
If latent curing agent is converted to reactive form upon exposure to moisture, then adhesive strength is improved, but extended mixing time without premature gelling is required
Solution Approach 1:
The patent performs preliminary blocking of the amine group in the ketimine component, creating a latent form that is stable during storage and mixing. This preliminary action prevents premature reaction while maintaining the capacity for subsequent activation by moisture, allowing extended mixing time without gelling.
Solution Approach 2:
The patent optimizes the molecular weight and chemical structure parameters of both the ketimine and amine reactive moiety components to ensure they remain liquid with appropriate viscosity ranges. This parameter optimization balances reactivity with stability, allowing sufficient mixing time while preventing premature gelling before application.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides a biocompatible, biodegradable, and effective adhesive with enhanced tissue adhesion and storage stability, suitable for various surgical applications, including internal use, with improved handling and mechanical properties, and the ability to prevent fluid leakage and minimize scarring.
Implementation Method 1
a ketimine moiety may be used as a latent curing agent that can be converted to a reactive curing agent, i.e., an amine moiety, in the presence of water
Implementation Method 2
the amine moiety may then react with the second component of the mixture, i.e., a reactive moiety such as an isocyanate, to form the desired cured adhesive and/or sealant
Data Source
AI summary
The invention relates to a novel moisture activated solvent-free latent curing adhesive or sealant mixture comprising (1) a selected poly(alkylene oxide)imine, and (2) a selected amine reactive moiety.