Moisture-Proof Membrane-Forming Composition for Pharmaceutical Products
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Solution Overview
Problem
Existing moisture-proof coatings for pharmaceutical and food products, such as those containing stearic acid, hydroxypropylcellulose, and poloxamer 124, do not provide sufficient moisture-proof properties, leading to issues like denaturation and deterioration of hygroscopic and water-reactive substances.
Innovation Solution
A membrane-forming composition comprising a combination of nonionic surfactants like sucrose fatty acid esters and polyoxyethylene sorbitan fatty acid esters, higher alcohol surfactants, and a fatty acid dispersed in a water-soluble polymer, which forms a coating layer to enhance moisture-proof properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional coating agents containing stearic acid, hydroxypropylcellulose and poloxamer 124 are used, then the coating can be applied to pharmaceutical and food products, but the moisture-proof property is insufficient leading to denaturation and deterioration of hygroscopic substances
Solution Approach 1:
The patent uses a composite coating system combining hydroxypropylcellulose (water-soluble polymer) with stearic acid (fatty acid) and poloxamer 124 (surfactant). This composite material creates a dual-function coating: the hydroxypropylcellulose forms the base coating layer while the stearic acid and poloxamer 124 provide moisture barrier properties. The synergistic combination resolves the contradiction by achieving both adequate coating formation and sufficient moisture-proof protection to prevent denaturation of hygroscopic substances.
Solution Approach 2:
The patent optimizes specific parameter ranges to improve moisture-proof properties: stearic acid content at 1-20 parts by mass per 100 parts by mass of hydroxypropylcellulose, poloxamer 124 at 0.1-10 parts by mass per 100 parts by mass of hydroxypropylcellulose, and coating film thickness at 1-10 μm. By adjusting these parameters within optimal ranges, the coating achieves enhanced moisture barrier functionality while maintaining coating integrity, thus preventing deterioration of water-reactive substances.
2Reliability
If existing coating formulations are used, then the coating can be formed on the product surface, but the moisture barrier function is inadequate allowing moisture absorption and deterioration
Solution Approach 1:
The patent creates a thin film coating (1-10 μm thickness) on the surface of pharmaceutical and food products. This flexible thin film comprises hydroxypropylcellulose as the base material with stearic acid and poloxamer 124 dispersed within it. The thin film structure provides effective moisture barrier protection while conforming to the product surface, preventing moisture absorption and maintaining the stability and integrity of hygroscopic substances within the product.
3Ease of manufacture
If conventional coating agents are applied, then the coating process can be performed, but the moisture-proof effectiveness is insufficient to prevent deterioration of taste and quality
Solution Approach 1:
The patent specifies optimal parameter ranges for the coating formulation: hydroxypropylcellulose viscosity at 5-500 cP, stearic acid at 1-20 parts by mass per 100 parts by mass of hydroxypropylcellulose, and poloxamer 124 at 0.1-10 parts by mass per 100 parts by mass of hydroxypropylcellulose. These parameter optimizations ensure the coating mixture has suitable rheology for application while forming a moisture-proof barrier that prevents deterioration of taste and quality in pharmaceutical and food products.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides excellent moisture-proof properties, preventing moisture absorption and maintaining the integrity of hygroscopic and water-reactive substances in pharmaceutical and food products.
Implementation Method 1
a membrane-forming composition, including at least one surfactant and a fatty acid dispersed in a liquid containing a water-soluble polymer, the at least one surfactant being selected from a nonionic surfactant selected from sucrose fatty acid esters and polyoxyethylene sorbitan fatty acid esters and a higher alcohol surfactant
Implementation Method 2
the composition provides excellent moisture-proof properties, preventing moisture absorption
Data Source
AI summary
A novel means capable of improving moisture-proof property of pharmaceutical products, food products and the like. The problem is solved by a membrane-forming composition, comprising at least one nonionic surfactant that is at least one from sucrose fatty acid esters and polyoxyethylene sorbitan fatty acid esters and a fatty acid dispersed in a liquid containing a water-soluble polymer.