Moldable Bone Composition Segmentation
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Solution Overview
Problem
Existing bone repair compositions struggle to maintain position and effectively promote new bone growth in osseous defects and bone voids, particularly in retaining shape during application.
Innovation Solution
A moldable bone composition is developed, comprising a mixture of cortical and cancellous bone in specific proportions, including demineralized and mineralized components, which can be freeze-dried and molded into desired shapes upon addition of a fluid, utilizing cortical shavings, powder, and crushed cancellous bone in defined ratios.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If bone repair composition is made malleable by adding collagen or gelatinous materials, then it can be molded into shape, but it loses structural stability and cannot retain position
Solution Approach 1:
The bone composition is segmented into multiple particle size fractions (fine particles <2mm, intermediate particles 2-5mm, coarse particles 5-10mm) that work together in combination. This segmentation allows each fraction to contribute different properties: fine particles provide moldability and filling, while coarse particles provide structural stability and position retention, resolving the contradiction between ease of operation and stability.
Solution Approach 2:
The invention creates a composite bone material combining three distinct particle size fractions of bone particles with specific percentage ranges (fine: 30-70%, intermediate: 20-50%, coarse: 10-40%). This composite structure integrates the advantages of different particle sizes, achieving both moldability from fine particles and position retention from coarse particles, while the intermediate particles bridge the gaps to enhance overall structural integrity.
2Ease of operation
If bone particles are made finer for better moldability, then the composition becomes more workable, but the structural strength decreases
Solution Approach 1:
Different regions of the bone composition have different particle size qualities optimized for their specific functions. Fine particles (<2mm) concentrated at 30-70% provide workability and filling capability in the bulk material, while coarse particles (5-10mm) at 10-40% provide structural strength where needed. This local quality differentiation resolves the contradiction between workability and structural strength.
Solution Approach 2:
The composite structure combines three particle size fractions with specific percentage ranges, where fine particles ensure workability and moldability, while coarse particles embedded within provide structural reinforcement. The intermediate particles (2-5mm) at 20-50% act as connectors between fine and coarse particles, creating a hierarchical composite that achieves both workability and structural strength simultaneously.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides a stable, osteoinductive material that can be molded and applied to bone defects, promoting effective bone repair and growth without visible cracks, suitable for treating osseous defects and bone voids.
Implementation Method 1
When subjected to a fluid, the composition can be molded to a desired shape
Implementation Method 2
The portions are free-dried and mixed together to form a freeze-dried moldable bone composition
Implementation Method 3
freeze-dried material packaged in jars wherein the packaged mixture is stored
Data Source
AI summary
A moldable bone composition consists of a mixture of: cortical bone and cancellous bone. The cortical bone is formed in three portions, a mineralized shaving portion and a demineralized shaving portion and a mineralized powder portion. The cancellous bone is formed in a mineralized crushed cancellous portion. The portions are free-dried and mixed together to form a freeze-dried moldable bone composition.