Moldable Bone Filler Composition for Stable Defect Repair
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Solution Overview
Problem
Existing bone repairing compositions are difficult to handle and shape, often dislodged by body fluids, and require significant manipulation during surgery, making them unsuitable for large defects and inefficient in achieving stable integration with the bone surface.
Innovation Solution
A method involving mixing demineralized bone with water, heating the mixture to form a carrier, and combining it with a bone material to create a moldable composition that can be molded into preformed shapes suitable for administration to the bone surface, providing a rigid and stable bone filler that adheres well to the site without easy displacement by body fluids.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If demineralized bone is used as a bone filler, then it is osteogenic and non-immunogenic, but it is dry and difficult to manipulate
Solution Approach 1:
The patent changes the physical state of demineralized bone from dry to hydrated by controlling moisture content (10-40% by weight), transforming it from a difficult-to-manipulate powder to a moldable paste that retains osteogenic properties while improving ease of handling and shaping
2Ease of operation
If bone filler is made malleable with wetting agents, then it becomes easier to manipulate, but it may become dislodged and carried away by body fluids
Solution Approach 1:
The patent optimizes moisture content to 10-40% by weight, creating a balance where the bone filler is moldable enough for easy handling yet contains sufficient solid content to maintain structural integrity and resistance to dislodgement by body fluids
Solution Approach 2:
The patent creates a composite material combining demineralized bone particles with a controlled amount of moisture, forming a paste-like composition that integrates the osteogenic properties of bone with the manipulability of a semi-solid matrix
3Adaptability or versatility
If surgeon sculpts the filler in the operating room, then it can fit the defect site configuration, but it requires significant time and manipulation
Solution Approach 1:
The patent enables surgeons to preliminarily shape the bone filler into desired configurations before surgery, storing pre-shaped fillers that require minimal manipulation during the operating room procedure while still allowing customization to fit specific defect geometries
4Reliability
If dry demineralized bone is used, then it is osteogenic, but it requires hydration during surgery which complicates the procedure
Solution Approach 1:
The patent pre-optimizes the moisture content parameter to 10-40% by weight, transforming the bone filler from a dry powder requiring surgical hydration to a pre-hydrated paste that is ready for immediate implantation, simplifying the surgical procedure while preserving osteogenic properties
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution results in a bone filler that is non-immunogenic, osteogenic, and resistant to dissolution by body fluids, offering enhanced strength and ease of hydration, allowing for efficient placement and integration into bone defects without the need for extensive sculpting during surgery.
Implementation Method 1
heating the mixture of demineralized bone and water to form a carrier
Data Source
Figure 1~4
AI summary
Formed compositions for application to a bone surface of a human or animal subject, comprising: a bone material; and a carrier comprising denatured demineralized bone, where the composition is formed into a shape suitable for administration to the bone. Methods are provided for making formed compositions for application to a bone surface of a human or animal subject comprise mixing a demineralized bone and water; heating the mixture to form a carrier; mixing the carrier with bone to form a moldable composition; and molding the moldable composition to produce a formed composition. Several apparatuses are provided in which to hydrate the formed bone composition. Methods of hydrating a formed bone composition are also provided.