Molecular Metadata Etches for Genetic Sample Verification
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Solution Overview
Problem
Existing genetic data verification and protection methods lack the ability to accurately and efficiently incorporate contextual metadata, leading to potential contamination, alteration, and computational inefficiencies in processing and sequencing.
Innovation Solution
The use of molecular etches that encode contextual metadata non-covalently with genetic samples, allowing for error detection and correction, contamination detection, and improved data integrity through a predefined library of non-interfering sequences.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If contextual metadata is incorporated into genetic samples using existing methods, then data verification capability is improved, but sample purity and accuracy deteriorate due to contamination and alteration
Solution Approach 1:
The patent separates contextual metadata from the genetic sample by encoding metadata into distinct molecular etches (short DNA/RNA sequences) that are pooled with but not covalently bound to the genetic material. This segmentation allows independent handling and verification of metadata without contaminating the genetic sample.
Solution Approach 2:
The patent introduces molecular etches as intermediary carriers that encode contextual metadata. These etches act as mediators between the metadata information and the genetic sample, allowing verification capability enhancement while preventing direct contamination of the genetic material through non-covalent pooling.
2Reliability
If contextual metadata is incorporated into genetic samples, then data protection capability is improved, but processing efficiency deteriorates due to computational overhead
Solution Approach 1:
The patent performs error detection and correction computations on the molecular etches during the sequencing process itself, before final data analysis. This preliminary action integrates verification into the existing workflow, avoiding separate computational overhead steps and maintaining processing efficiency.
Solution Approach 2:
The patent implements self-verifying metadata systems where the molecular etches contain embedded error-detection and error-correction codes that automatically verify their own integrity during sequencing, eliminating the need for external verification computations and maintaining processing efficiency.
3Loss of information
If molecular etches are bound covalently to genetic samples, then metadata retention is improved, but sample integrity deteriorates
Solution Approach 1:
The patent creates a separate copy of contextual metadata in the form of molecular etches that are pooled with the genetic sample but not covalently bound. This copying approach retains all metadata information while preserving the original genetic sample's integrity, as the etches can be independently sequenced and verified.
Data Source
AI summary
In some embodiments, a method for verifying genetic samples using contextual metadata can include receiving at least one genetic sample, identifying one or more contextual parameters associated with the at least one genetic sample, obtaining one or more etches selected from a set of etches to encode the one or more contextual parameters, and pooling the one or more etches with the at least one genetic sample in a sample environment, wherein pooling prevents binding of the one or more etches to the at least one genetic sample.