Monascus Pilosus Fermentation for Weight Loss and Gut Microbiota
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Solution Overview
Problem
Current treatments for overweight and obesity, such as exercise, calorie-controlled diets, and medications, are often unsustainable and have adverse side effects, while surgical procedures are costly and uncertain, necessitating a safer and more effective alternative.
Innovation Solution
A composition containing Monascus pilosus fermented products, specifically Monascinol, is used to enhance the abundance of beneficial gut bacteria, such as Bacteroidales and Verrucomicrobiales, to promote weight loss and improve gut microbiota without adverse effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Weight of moving object
If traditional weight loss treatments (exercise, calorie-controlled diet, medications) are used, then weight loss can be achieved, but they are often unsustainable and have adverse side effects
Solution Approach 1:
The composition utilizes the body's own metabolic processes and gut microbiota to achieve weight loss. Monascus pilosus ferments carbohydrates into short-chain fatty acids and modulates gut bacteria composition, allowing the body to naturally regulate weight without external interventions like strict diets or exercises that are hard to maintain long-term
Solution Approach 2:
The invention changes the biochemical parameters of weight loss by introducing Monascus pilosus fermentation products that modify gut microbiota composition and metabolic pathways. This shifts the mechanism from physical restriction (calorie control) or mechanical action (exercise) to biochemical modulation, achieving more sustainable and safer weight loss
2Weight of moving object
If surgical procedures (liposuction, gastrectomy, gastric bypass) are used for weight loss, then significant weight reduction is achieved, but costs are higher and procedures are uncertain
Solution Approach 1:
The invention replaces mechanical surgical interventions with a biochemical composition based on Monascus pilosus fermentation. Instead of physically altering the body through surgery, the composition works through metabolic and microbial mechanisms, making weight loss accessible without invasive procedures, higher costs, and surgical risks
3Weight of moving object
If drugs (metabolic stimulants, appetite suppressants, starch blockers) are used, then weight loss is achieved, but they cause adverse effects on the patient's body
Solution Approach 1:
The invention converts the potential harm of conventional drugs with adverse side effects into a beneficial natural fermentation process. Monascus pilosus, a naturally occurring fungus, ferments carbohydrates into useful short-chain fatty acids and modulates gut microbiota, achieving weight loss through beneficial metabolic pathways rather than harmful pharmaceutical interventions
Solution Approach 2:
The composition acts as a natural intermediary between diet and weight loss. Instead of directly stimulating appetite suppression or metabolic acceleration through drugs, Monascus pilosus fermentation products serve as intermediaries that modulate gut microbiota and metabolic processes, achieving weight loss through gentle, natural biochemical mediation without adverse side effects
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces body weight and enhances the gut microbiota by increasing the abundance of beneficial bacteria, addressing obesity-related health issues like cardiovascular disease, diabetes, and cancer, while being safe and accessible.
Implementation Method 1
Monascus pilosus has been used to reduce weight and improve the composition of gut microbiota. The composition includes Monascus pilosus and/or its fermented product
Data Source
AI summary
The main purpose of the present invention is to provide a Monascus pilosus strain and a composition for weight loss and improvement of gut microbiota composition. The composition comprises Monascus pilosus and/or its fermented product, or comprises an active ingredient of its fermented product. Another objective of the present invention is to provide a use of Monascus pilosus in the manufacture of a composition for weight loss and improvement of gut microbiota composition. The composition of the present invention has the ability to reduce body weight and improve gut microbiota, such as lowering the ratio of Firmicutes to Bacteroidetes.