Monetite Cement Composites for Bone Defect Repair

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Solution Overview

Problem

Current bioceramic formulations for bone void fillers have a low bone induction capability and difficulty in combining this with a tailored resorption rate, making them unsuitable for large and complex bone defects, especially in the cranium, and are challenging to handle in industrial settings.

Innovation Solution

Calcium phosphate monetite cement-forming compositions comprising monocalcium phosphate, β-tricalcium phosphate, and β-dicalcium pyrophosphate, with a non-aqueous water-miscible liquid, which can be mixed with an aqueous liquid to achieve hardening, forming implants with a controlled resorption rate and improved bone induction.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional bioceramic formulations are used for bone void filling, then the material can be applied to fill defects, but the bone induction capability is low and resorption rate cannot be tailored

Engineering Contradiction:

Improvebone induction capabilityVSAvoidtailored resorption rate

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent employs composite calcium phosphate cement formulations containing multiple phases (monetite, brushite, and other calcium phosphates) in specific ratios. This composite approach allows simultaneous achievement of high bone induction capability through monetite phase and controlled resorption rate through the combined behavior of different phases, resolving the contradiction between reliability and adaptability.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent systematically varies compositional parameters (phase ratios, particle size distributions, chemical composition) of the calcium phosphate cement to optimize both bone induction and resorption characteristics. By changing these parameters, the formulation achieves tailored resorption rates while maintaining high bone induction capability.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If bioceramic formulations with bone induction capability are used, then bone formation can be induced, but the material handling and moulding for complex shapes becomes difficult

Engineering Contradiction:

Improvebone induction capabilityVSAvoidmaterial handling and moulding

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent optimizes the rheological parameters of the cement formulation by adjusting liquid-to-powder ratios, viscosity modifiers, and setting time characteristics. This allows the material to remain workable and easily mouldable for complex shapes during the setting period while still achieving high bone induction capability.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent prepares the cement formulation with pre-optimized composition and rheological properties before application, ensuring that the material has ideal flow and setting characteristics for easy handling and moulding into complex shapes, while maintaining bone induction capability.

Inventive Principle:

Principle #10Preliminary action

3Productivity

If fast resorbing materials are used for bone defect repair, then the material can be replaced by natural bone quickly, but the structural support duration is insufficient

Engineering Contradiction:

Improvebone repair speedVSAvoidstructural support duration

Core Design Contradiction:

ProductivityVSDuration of action of stationary object

Solution Approach 1:

The patent creates a composite calcium phosphate cement with multiple phases having different resorption rates. The monetite phase provides fast initial resorption and bone induction, while other phases (brushite, tricalcium phosphate) provide sustained structural support, achieving both quick bone repair and adequate structural support duration.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent designs the cement formulation to exhibit staged resorption behavior, where different phases resorb at different rates over time. This periodic action pattern ensures that structural support is maintained throughout the bone healing process while allowing progressive replacement by natural bone.

Inventive Principle:

Principle #19Periodic action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The monetite cement implants exhibit optimal resorption rates and enhanced bone formation, facilitating easier handling and effective repair of complex bone defects with reduced resorption over time.

Implementation Method 1

adapted to be mixed with an aqueous liquid or exposed to an aqueous liquid to achieve hardening

Methodology Applied

Scientific EffectHardening: Phase Change

Implementation Method 2

slowing implant resorption in a bone defect repair

Methodology Applied

Scientific EffectResorption: Decomposition (biological)

Data Source

PatentEP2931325B1Cement-forming compositions, monetite cements, implants and methods for correcting bone defects

Publication Date: 2020.02.19 OSSDSIGN

Figure 1

AI summary

A calcium phosphate monetite cement-forming composition comprises a monetite- forming calcium-based precursor powder and from 3 to 30 wt %, based on the weight of the precursor powder, of dicalcium pyrophosphate powder. Monetite cements formed form such compositions may be used in implants for correcting bone defects. Methods for bone defect repair employ implants formed from such monetite cements and slow implant resorption and/or improve in vivo bone induction in a patient.