Monosaccharide and Adenosine Cosmetic Composition for Skin Aging
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Solution Overview
Problem
Current cosmetic and dermatological treatments for skin aging, particularly wrinkle formation and epidermal atrophy, face challenges with the instability of retinol and side effects such as skin irritation, necessitating alternative compounds that effectively stimulate keratinocyte and fibroblast proliferation and collagen synthesis while addressing expression lines and skin contractions.
Innovation Solution
A composition combining monosaccharides like mannose and rhamnose with adenosine or its analogues, which synergistically stimulate epidermal renewal, reduce wrinkle formation, and enhance collagen synthesis, thereby addressing skin aging and expression lines without the drawbacks of retinol.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If retinol is used to stimulate keratinocyte and fibroblast proliferation and collagen synthesis, then skin aging signs are reduced, but the composition becomes unstable and causes skin irritation
Solution Approach 1:
The patent extracts and isolates adenosine as the specific active compound responsible for the beneficial effects of retinol, separating it from the instability and irritation problems associated with retinol itself. This allows the use of adenosine's proliferative and collagen-stimulating properties without retinol's harmful side effects
Solution Approach 2:
The patent changes the chemical parameter from retinol (a vitamin A derivative) to adenosine (a nucleoside), fundamentally altering the molecular structure while maintaining the biological function of stimulating cell proliferation and collagen synthesis. This parameter change resolves both stability and irritation issues
2Strength
If retinol is used to treat epidermal atrophy and wrinkle formation, then skin thickness and collagen content increase, but side effects such as skin irritation occur
Solution Approach 1:
The patent extracts adenosine as the specific active component that drives collagen synthesis and epidermal thickening, separating this beneficial effect from the irritation side effects of retinol. Adenosine is shown to stimulate fibroblast proliferation and collagen production without causing skin irritation
Solution Approach 2:
The patent uses adenosine, a naturally occurring nucleoside that is metabolized and replaced in the body, as an alternative to retinol. This allows for repeated application without accumulation of harmful effects, as adenosine is naturally turnovered in skin cells
3Reliability
If current cosmetic treatments are used to address expression lines and skin contractions, then some efficacy is achieved, but the treatments lack stability and cause irritation
Solution Approach 1:
The patent uses adenosine as an intermediary substance that mediates between the cosmetic formulation and skin cells. Adenosine acts as a natural signaling molecule that skin cells already recognize and respond to, providing stable and tolerable treatment for expression lines and skin contractions without the irritation caused by retinol
Data Source
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AI summary
The present invention relates to a composition, in particular cosmetic and/or dermatological, comprising in a physiologically acceptable medium, the association of at least one monosaccharide chosen from mannose, rhamnose and their mixture, and at least one additional compound chosen from adenosine, one of its analogues and their mixture.