Montmorillonite Clay Adsorbs Clostridial Toxins
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Solution Overview
Problem
Current methods for managing Clostridium-induced diseases in poultry and livestock are inadequate, as they often rely on antibiotics and do not effectively address the economic and health burdens caused by Clostridium perfringens, which leads to necrotic enteritis and other enteric diseases.
Innovation Solution
A composition comprising a clay, a yeast product, and a functional amino acid like glutamate, specifically calcium montmorillonite clay, Pichia guilliermondii yeast product, and monosodium glutamate, which adsorbs toxins and alleviates necrotic enteritis by binding clostridial toxins and improving gastrointestinal health.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If antibiotics are used to control Clostridium diseases, then disease control effectiveness is improved, but safety and economic cost are worsened
Solution Approach 1:
The patent introduces clay minerals (montmorillonite, bentonite) as intermediary substances that bind to Clostridium toxins in the intestine, preventing them from damaging tissue. The clay acts as a mediator between the toxin and the intestinal wall, neutralizing the harmful effect without using antibiotics.
Solution Approach 2:
The patent converts the harmful toxins produced by Clostridium into beneficial binding opportunities for clay minerals. The toxins that would normally cause necrotic enteritis are instead captured by the clay, transforming a harmful substance into a controlled interaction that protects the animal.
2Reliability
If antibiotics are used to control Clostridium diseases, then disease control effectiveness is improved, but economic cost is worsened
Solution Approach 1:
The patent employs inexpensive clay minerals (montmorillonite, bentonite) as disposable binding agents that can be administered in feed or water. These clays are low-cost materials that effectively neutralize toxins without the high economic burden of antibiotic treatments.
3Object-affected harmful factors
If clay is used to bind toxins, then safety is improved, but toxin binding effectiveness is worsened compared to antibiotics
Solution Approach 1:
The patent creates a composite approach by combining clay minerals with organic compounds (fatty acids, amino acids, plant extracts) to enhance toxin binding effectiveness. This composite material strategy overcomes the limitation of pure clay while maintaining safety advantages.
Solution Approach 2:
The patent modifies the properties of clay materials through various treatments (heat treatment, chemical modification, particle size reduction) to optimize their toxin binding capacity. By changing physical and chemical parameters of the clay, effectiveness is enhanced while maintaining safety.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces the severity of necrotic enteritis and other clostridial diseases by enhancing toxin binding and immune response, offering a safer and more economical alternative to antibiotics.
Implementation Method 1
Applicants have shown in vitro that certain clays can adsorb toxins from Clostridium difficile and Clostridium perfringens. Applicants have shown in vivo that certain clays or clay formulations can alleviate necrotic enteritis in chickens, a disease associated with Clostridium perfringens.
Data Source
AI summary
The present invention relates to a combination of an anti-toxin, The present invention relates to a combination of an anti-toxin, an immunomodulator and a component that provides energy to mucosal cells, which may be useful for decreasing effects of Clostridia sp. or coccidia sp based diseases or other enteric diseases or by generally improving gastro intestinal health or function.