Montmorillonite-PVA Barrier Layer for Flexible Medical Patches
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Solution Overview
Problem
Medical adhesive patches with flexible supports face issues maintaining barrier properties during elongation, leading to cracks and degradation of barrier layers, which can result in inadequate medicine administration and adverse effects from plasticizers.
Innovation Solution
A medical adhesive patch with a support film containing a barrier layer of polyvinyl alcohol and montmorillonite, laminated on a polyurethane surface, and an adhesive layer with a rubber-based polymer and specific plasticizers, ensuring excellent barrier properties even with elongation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a flexible support material is used to allow elongation during attachment and use, then flexibility and adaptability are improved, but the barrier layer develops cracks and loses barrier properties
Solution Approach 1:
The barrier layer is constructed as a composite material containing polyvinyl alcohol as the base polymer and montmorillonite as the reinforcing filler. This composite structure provides both flexibility and crack resistance, allowing the barrier layer to maintain its integrity during support elongation while preserving barrier properties against plasticizer and medicine migration.
Solution Approach 2:
The patent optimizes the montmorillonite content parameter within a specific range (5-20 parts by weight per 100 parts of polyvinyl alcohol) and controls the degree of saponification (70-95.5%). These parameter adjustments balance the flexibility and barrier performance, ensuring the barrier layer can accommodate elongation without cracking while maintaining effective barrier properties.
2Reliability
If the barrier layer is made thicker or more rigid to improve barrier properties, then barrier performance is improved, but flexibility and ability to respond to shape changes deteriorate
Solution Approach 1:
The patent achieves optimal barrier properties through careful control of material parameters rather than increasing thickness. By adjusting the montmorillonite content (5-20 parts by weight per 100 parts of polyvinyl alcohol) and degree of saponification (70-95.5%), the barrier layer achieves effective barrier performance while maintaining flexibility and the ability to respond to shape changes during elongation.
3Reliability
If a barrier coating material is applied to prevent plasticizer adsorption, then barrier properties are improved, but the support loses flexibility and elongation capability
Solution Approach 1:
The barrier layer is constructed as a composite material containing polyvinyl alcohol as the base polymer and montmorillonite as the reinforcing filler. This composite structure provides both flexibility and barrier performance, allowing the barrier layer to maintain its integrity during support elongation while preserving barrier properties against plasticizer and medicine migration.
Solution Approach 2:
The patent optimizes the montmorillonite content parameter within a specific range (5-20 parts by weight per 100 parts of polyvinyl alcohol) and controls the degree of saponification (70-95.5%). These parameter adjustments balance the flexibility and barrier performance, ensuring the barrier layer can accommodate elongation without cracking while maintaining effective barrier properties.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The patch maintains excellent barrier properties during and after attachment, preventing medicine and plasticizer transition to the support, thus ensuring effective and prolonged medicine administration without adverse effects.
Implementation Method 1
Since there is a concern of a negative effect due to adsorption of a plasticizer depending on the material of a support, it is preferable that at least a surface of the support which comes in contact with the adhesive layer has barrier properties.
Implementation Method 2
it is necessary for the support to obtain a barrier property
Implementation Method 3
a barrier layer containing polyvinyl alcohol with a degree of saponification in a range equal to or more than 70% and equal to or less than 95.5% and montmorillonite, the barrier layer being laminated on one surface of a support including polyurethane
Data Source
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AI summary
A medical adhesive patch, includes: a support film including a barrier layer which contains a water-soluble polymer compound and montmorillonite, and which is laminated on one surface of a support including polyurethane; an adhesive layer which contains a medicine and a plasticizer, and which is laminated on a barrier layer of the support film, the medical adhesive patch has a percentage content of montmorillonite in the barrier layer is equal to or more than 2 percent by weight and equal to or less than 22 percent by weight.