Morchella Mycelia Composition for Testosterone and Sperm Quality
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Solution Overview
Problem
Reproductive function disturbances, such as decreased testosterone levels, increased oxidative stress, and structural integrity issues in testicular tissue, are exacerbated by obesity and metabolic syndrome, particularly in diabetic individuals, leading to impaired sperm quality and fertility.
Innovation Solution
A composition comprising an active substance derived from Morchella mycelia, obtained through solid-state, liquid culture, and fermentation processes, which is administered to increase testosterone levels, reduce abnormal sperm proportions, and decrease oxidative stress in sperms, thereby improving testicular tissue integrity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If obesity and metabolic syndrome are present, then testosterone levels decrease and sperm quality deteriorates, but reproductive function is impaired
Solution Approach 1:
The patent uses an active substance from Morchella as an intermediary compound to mediate between the adverse metabolic state (obesity/diabetes) and testicular function. This substance acts as a protective agent that intervenes in the harmful pathway, reducing oxidative stress and preventing testosterone degradation without requiring weight loss or metabolic correction first.
Solution Approach 2:
The patent converts the harmful oxidative stress environment (high ROS levels in obesity/diabetes) into a beneficial state by introducing an antioxidant substance from Morchella. This substance transforms the toxic oxidative environment into a protective one, where the same oxidative stress conditions that would normally harm sperm are instead counteracted by the mushroom-derived antioxidant, turning the harmful metabolic state into an opportunity for therapeutic intervention.
2Object-affected harmful factors
If oxidative stress increases in sperms, then sperm quality decreases, but structural integrity of testicular tissue is compromised
Solution Approach 1:
The patent applies the blessing in disguise principle by using the active substance from Morchella to convert the harmful oxidative stress into a beneficial protective effect. The substance acts as an antioxidant that neutralizes ROS, transforming the toxic oxidative environment into a protective state that preserves sperm quality and testicular tissue integrity.
Solution Approach 2:
The active substance from Morchella serves as an intermediary antioxidant agent that mediates between the harmful oxidative stress and the testicular tissue. It intervenes in the oxidative damage pathway, providing protection without requiring changes to the underlying metabolic condition, thus preserving structural integrity while counteracting oxidative stress.
3Quantity of substance
If abnormal sperm proportion increases, then fertility decreases, but reproductive function disturbance occurs
Solution Approach 1:
The patent introduces the active substance from Morchella as an intermediary protective agent that acts on sperm cells directly. This substance reduces the proportion of abnormal sperm by protecting against oxidative damage during spermatogenesis, thereby improving fertility outcomes without requiring correction of the underlying metabolic syndrome or obesity.
Data Source
AI summary
The present invention provides an active substance of Morchella, its use and a composition thereof for improving disturbance of reproductive function, especially, for manufacturing a pharmaceutical composition to improve disturbance of reproductive function induced by obesity or metabolic syndrome. The composition with the active substance of Morchella can effectively improve the structural integrity of testicular tissues and sperm, increase testosterone levels in the blood, and reduce the oxidation stress in sperms.