Moringa Extract Benzyl Glucosinolate Stabilization
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Moringa extracts face challenges in maintaining high levels of benzyl glucosinolates due to decomposition during extraction, and contain alkaloids that pose safety concerns, especially for pregnant women, while existing PPAR activators from natural sources lack sufficient activation efficacy and stability.
Innovation Solution
A moringa extract with a benzyl glucosinolate content of 6% or more, extracted under specific conditions (pre-treatment at 80°C or higher and solvent extraction at 10° to 50°C) and blended with excipients like dextrin to inhibit decomposition, ensuring safety and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If moringa is extracted using conventional methods, then the extract contains various active ingredients, but benzyl glucosinolates decompose during extraction reducing their content
Solution Approach 1:
The moringa material is pre-treated at 80°C or higher before extraction to inactivate enzymes that would otherwise decompose benzyl glucosinolates during the extraction process. This preliminary heat treatment preserves the benzyl glucosinolate content while allowing extraction of other active ingredients.
Solution Approach 2:
The extraction is performed at a controlled temperature of 10° to 50°C, which is low enough to prevent thermal decomposition of benzyl glucosinolates during the extraction process itself, while still allowing adequate extraction of other compounds.
2Reliability
If moringa extract is produced to contain high levels of active ingredients, then physiological functions are enhanced, but alkaloids are also present creating safety concerns
Solution Approach 1:
The extraction process selectively extracts benzyl glucosinolates and other desired active ingredients while leaving alkaloids behind in the moringa material, or removes alkaloids through additional purification steps, thereby producing an extract that is safe for consumption including for pregnant women.
3Reliability
If natural PPAR activators are used, then safety is improved compared to synthetic agents, but activation efficacy and stability are insufficient
Solution Approach 1:
The extracted moringa extract contains a composite profile of multiple active ingredients including benzyl glucosinolates, flavonoids, and other phytochemicals that work synergistically to provide both stable and effective PPAR activation, combining the benefits of multiple natural compounds.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting moringa extract provides enhanced physiological functions, safety for consumption, and effective PPAR activation, maintaining stability and efficacy as a natural PPAR activator.
Implementation Method 1
extracting moringa pre-treated at 80° C. or higher
Implementation Method 2
extracting with a solvent at a temperature of from 10° to 50° C.
Implementation Method 3
blended with excipients like dextrin to inhibit decomposition
Data Source
AI summary
A moringa extract containing a benzyl glucosinolate in a content of 6% by mass or more, calculated as a dry solid content of the extract, wherein the extract does not substantially contain an alkaloid. The moringa extract of the present invention for solving a first aspect is useful in the field of foodstuff or the like. Also, the PPAR activator of the present invention for solving a second aspect has excellent PPAR activation action, and has no disadvantages in side effects, so that it can be ingested for long term, which can be preferably used in foodstuff and the like. Therefore, the PPAR activator of the present invention for solving a second aspect can be expected to be used as a food, a supplement or a medicament not only for prevention of disease such as insulin resistance, hyperinsulinism, Type 2 diabetes, hypertension, hyperlipidemia, arterial sclerosis and obesity, but also for fatigue recovery or endurance improvement by improving basal metabolism. In addition, a benzyl glucosinolate-containing composition for solving a third aspect is useful in the field of foodstuff or the like.