Morus australis Poir Extract Antitussive Composition
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Solution Overview
Problem
There is a lack of a commercially viable antitussive agent in Taiwan using Morus alba L., which is not popular, necessitating the development of an antitussive composition using Morus australis Poir.
Innovation Solution
An antitussive composition is created using Morus australis Poir extract, extracted with water, ethanol, acetone, or a combination thereof, and processed through filtration and reverse phase column elution to produce a concentrate effective in treating coughs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If Morus alba L. is used to manufacture an antitussive agent, then the agent has proven antitussive efficacy, but the natural amount of Morus alba L. is not popular in Taiwan making it commercially unviable
Solution Approach 1:
The patent changes the botanical source parameter from Morus alba L. to Morus australis Poir., which is locally popular in Taiwan. This substitution maintains the antitussive efficacy while improving commercial viability by using a readily available local resource.
Solution Approach 2:
The patent creates a substitute composition using Morus australis Poir. that copies the antitussive properties of Morus alba L. The extract from Morus australis Poir. serves as a functional equivalent, replicating the therapeutic effect without requiring the original species.
2Ease of manufacture
If Morus australis Poir. extract is used to create an antitussive composition, then commercial viability is improved, but the extract requires complex processing steps including filtration, concentration, and reverse phase column elution
Solution Approach 1:
The patent divides the processing into distinct sequential steps: extraction, filtration, concentration, and reverse phase column elution. Each step handles a specific aspect of purification, making the complex process more manageable and controllable despite the multiple operations required.
Solution Approach 2:
The patent uses reverse phase column elution as an intermediary purification step between extraction and final product preparation. This intermediate step separates and purifies the active components from the crude extract, ensuring product quality while maintaining commercial viability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces coughing by more than 30% when administered at 2 g/kg body weight, demonstrating its efficacy in relieving and preventing coughs.
Implementation Method 1
extracting the roots (or root-bark) of the Morus australis Poir with water, ethanol, acetone, ethyl acetate, or a combination thereof to obtain a crude extract
Implementation Method 2
filtering the crude extract by a filter to obtain a filtrate
Implementation Method 3
concentrating the filtrate by 10 times and then adding an equal amount of water to obtain a concentrate
Implementation Method 4
loading the concentrate to a reverse phase column; eluting the reverse phase column with an ethanol solution, and collecting the ethanol eluate
Data Source
AI summary
An antitussive composition is provided. A pharmaceutical composition for relieving, preventing and/or treating a cough includes a sufficient amount of the Morus australis Poir extract as an active component. The effective Morus australis Poir extract is prepared by extracting the root-bark of the Morus australis Poir with water, ethanol, acetone, ethyl acetate, or a combination thereof. The crude extract can be further fractioned by ultrafiltration or reverse phase column.