Morus Root Extract Tyrosinase Inhibition via Prenylated Polyphenols
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Solution Overview
Problem
There is a need for new natural compounds that effectively inhibit tyrosinase activity to address the growing demand in cosmetics and pharmaceuticals for skin whitening and anti-aging applications, as existing inhibitors have limitations in efficacy and specificity.
Innovation Solution
A root extract of Morus plants, specifically Morus alba and Morus nigra, rich in prenylated polyphenols such as wittiorumine F, mulberrofuran T, moracenin A, and kuwanone C, is developed using a process that enhances their tyrosinase inhibitory activity and stability, allowing for their use in cosmetic and pharmaceutical compositions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If extracts from Morus plants are used for skin whitening applications, then tyrosinase inhibitory activity is achieved, but existing inhibitors have limitations in efficacy and specificity
Solution Approach 1:
The patent changes the chemical parameters by identifying and isolating specific prenylated polyphenol compounds (wittiorumin F, mulberrofuran T, moracenins, kuwanones) with optimized molecular structures that exhibit enhanced tyrosinase inhibitory activity compared to conventional inhibitors, thereby improving both efficacy and specificity
Solution Approach 2:
The patent extracts and isolates specific active compounds from Morus plant roots through systematic extraction and purification processes, separating the highly active prenymlared polyphenols from other plant constituents to achieve concentrated and specific tyrosinase inhibition
2Quantity of substance
If root extract is obtained through traditional extraction methods, then compounds are extracted, but plant survival may be compromised
Solution Approach 1:
The patent applies extraction methods that selectively remove desired compounds from the plant roots while preserving the living plant, enabling repeated extractions from the same root system over time without compromising plant viability
Solution Approach 2:
The patent performs preliminary optimization of extraction parameters (solvent selection, temperature, time) to maximize compound yield under conditions that maintain plant health, allowing sustainable extraction practices
3Productivity
If existing tyrosinase inhibitors are used, then skin whitening effect is achieved, but efficacy is limited
Solution Approach 1:
The patent achieves superior efficacy by identifying compounds with specific prenymlated polyphenol structures that exhibit stronger tyrosinase binding affinity and inhibition constants compared to conventional inhibitors, directly improving the skin whitening effect
Solution Approach 2:
The patent utilizes a composite of multiple prenymlared polyphenol compounds working synergistically, where the combination of wittiorumin F, mulberrofuran T, moracenins, and kuwanones produces enhanced inhibitory activity greater than individual compounds alone
Data Source
Figure 1A~1C
Figure 2
Figure 3A~3B
AI summary
The present invention concerns a root extract from plants of the Morus genus (in particular Morus albaet, Morus nigra) that is rich in prenylated polyphenols chosen from: moracenin A, moracenin B, kuwanon C, wittiorumin F and mulberrofuran T, a method for preparing such an extract and a cosmetic composition and a pharmaceutical or nutraceutical composition, said compositions comprising, as the active ingredient, at least one root extract from plants of the Morus genus according to the invention.