Sample Processing Module Array Handling System and Methods
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Solution Overview
Problem
Existing high-throughput biological sample processing systems are hindered by inefficiencies, high costs, and space requirements, leading to delays and increased healthcare costs, particularly in facilities with limited access and space constraints.
Innovation Solution
A high-throughput handling system with a cylindrical array of diagnostic assay modules, supported by a movable array support assembly, allows for rapid loading and unloading of diagnostic assay cartridges using elevators and a loader mechanism, enabling simultaneous processing of multiple samples while maintaining a controlled environment and reducing space requirements.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional high throughput systems are used, then processing capacity is improved, but space requirements and installation complexity increase significantly
Solution Approach 1:
The system divides the high-throughput processing capability into multiple independent diagnostic assay modules that can be individually loaded into the array. Each module contains a complete diagnostic assay system and can be independently replaced or serviced, allowing the system to maintain high processing capacity while using a compact footprint through modular architecture.
Solution Approach 2:
The diagnostic assay modules are nested within the array structure, with multiple modules arranged in a compact configuration. The loader mechanism is integrated within the same housing, creating a space-efficient nested arrangement where the loader serves the array from within the same enclosure, significantly reducing the overall space requirement compared to external loader configurations.
2Ease of manufacture
If batch processing is used to improve cost efficiency, then processing cost is reduced, but turnaround time increases
Solution Approach 1:
The system enables continuous processing by allowing multiple diagnostic assay modules to be loaded into the array and processed simultaneously. The loader can continuously load new modules as others are being processed or unloaded, eliminating idle time and achieving continuous useful action throughout the day, thereby reducing overall turnaround time while maintaining cost efficiency through automated high-volume processing.
Solution Approach 2:
Diagnostic assay modules are prepared and loaded into the array in advance before samples are received. This preliminary loading of ready-to-process modules ensures that when samples arrive, processing can begin immediately without waiting for module preparation, significantly reducing turnaround time while the automated system maintains cost efficiency through continuous operation.
3Speed
If large scale high throughput systems are deployed, then processing speed is improved, but facility modification requirements increase
Solution Approach 1:
The system is designed with universal interfaces and standardized mounting mechanisms that allow the diagnostic assay modules to be installed in various facility configurations. The array can accommodate different numbers and types of modules, making the system adaptable to different facility sizes and requirements without requiring custom installation modifications, thereby maintaining ease of installation while achieving high processing speed.
Solution Approach 2:
The array structure incorporates movable and adjustable components that allow flexible configuration and reconfiguration of the diagnostic assay modules. The loader mechanism can be positioned and adjusted to accommodate different module arrangements, enabling the system to adapt to various facility layouts without requiring permanent structural modifications, thus maintaining installation ease while supporting high processing speed capabilities.
Data Source
AI summary
A handling system for high throughput processing of a large volume of biological samples is provided herein. Such systems can include an array support assembly that supports multiple diagnostic assay modules in an array having at least two dimensions, a loader that loads multiple diagnostic assay cartridges within the multiple diagnostic assay modules. The array support assembly can be movable relative the loader to facilitate loading and unloading so as to provide more efficient processing.