Multimodal MPI Fixation and Registration Calibration System

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Solution Overview

Problem

Existing fixation and registration calibration devices for magnetic particle imaging (MPI) cannot effectively fix objects based on MPI characteristics or flexibly select magnetic particle calibration objects, making it difficult to fuse MPI with other structural imaging modalities.

Innovation Solution

A fixation and registration calibration system comprising an upper limiting device, a lower limiting device, an auxiliary clamping device, and an MPI calibration sample, with adjustable components and magnetic particle calibration holes, allowing for precise spatial position registration and flexible clamping to accommodate various object sizes and positions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Adaptability or versatility

If existing fixation devices are used for MPI, then the object can be fixed during imaging, but the device cannot flexibly select magnetic particle calibration objects or adapt to different object sizes and positions

Engineering Contradiction:

Improveflexibility to select calibration objects and adapt to different object sizesVSAvoidspatial registration accuracy

Core Design Contradiction:

Adaptability or versatilityVSMeasurement precision

Solution Approach 1:

The fixation device integrates multiple functions: it can fix different sized objects (rabbits, mice, etc.), hold various types of calibration objects (phantoms, beads, etc.), and provide both mechanical fixation and magnetic particle calibration capabilities in a single system, eliminating the need for separate fixation and calibration devices

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

The device employs adjustable components including movable clamping arms with position-adjustable clamps, adjustable-height support plates, and movable calibration object holders that can be positioned at different locations within the imaging field, allowing dynamic adaptation to various object sizes and imaging requirements while maintaining precise spatial registration

Inventive Principle:

Principle #15Dynamics

2Stability of the object's composition

If fixed fixation structures are used, then the object remains stable during imaging, but the device cannot accommodate various object sizes and positions

Engineering Contradiction:

Improveobject stability during imagingVSAvoidaccommodation of various object sizes and positions

Core Design Contradiction:

Stability of the object's compositionVSAdaptability or versatility

Solution Approach 1:

The fixation structure transforms from static to dynamic through movable clamping arms that can be adjusted to different positions, height-adjustable support plates that adapt to various object sizes, and repositionable calibration object holders, enabling the same structure to stably fix different objects (from small mice to larger rabbits) while maintaining imaging stability

Inventive Principle:

Principle #15Dynamics

Solution Approach 2:

The fixation device is divided into independent functional modules: separate clamping mechanisms for different sides, independent support plates for height adjustment, and movable calibration object holders, allowing each component to be adjusted independently to accommodate various object sizes and positions while maintaining overall stability

Inventive Principle:

Principle #1Segmentation

3Measurement precision

If MPI is combined with CT or MRI for structural information, then spatial location can be provided, but the fixation and registration becomes more complex

Engineering Contradiction:

Improvespatial location accuracyVSAvoidfixation and registration system complexity

Core Design Contradiction:

Measurement precisionVSDevice complexity

Solution Approach 1:

The device merges the fixation function and calibration function into a single integrated system, where the same mechanical structure provides both object fixation and calibration object positioning, eliminating the need for separate fixation devices and calibration tools for each imaging modality, thereby simplifying the overall system while maintaining precise spatial registration across MPI, CT, and MRI

Inventive Principle:

Principle #5Merging (Combining)

Data Source

PatentUS11940507B1Fixation and registration calibration system for multimodal magnetic particle imaging

Publication Date: 2024.03.26 BEIHANG UNIV

AI summary

A fixation and registration calibration system for multimodal MPI is provided. The fixation and registration calibration system includes an upper limiting device connected to a lower limiting device by a hand screw and an adjustable position component, where the upper limiting device and the lower limiting device each are symmetrical about the adjustable position component; an auxiliary clamping device is fixed at an upper end of the upper limiting device; the upper limiting device, the lower limiting device, and the auxiliary clamping device are provided with magnetic particle calibration holes at different positions; and an MPI calibration sample is provided through the magnetic particle calibration holes to achieve spatial position registration calibration. The fixation and registration calibration system achieves fixation of the detected object for MPI, flexible spatial position calibration based on magnetic particles, and stable and reliable multimodal MPI.