MPI-FMT Multimodal Imaging System for Small Animal Lesion Detection
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Magnetic particle imaging (MPI) has low resolution and fluorescence molecular tomography (FMT) has an insufficient field of view, leading to low accuracy in image reconstruction for detecting small lesions and anatomical structures.
Innovation Solution
A multimodal imaging system combining MPI and FMT, featuring a gradient coil for creating a static field-free line, a driving coil for controlling the magnetic field, a reception coil for nonlinear signal acquisition, and a fluorescence camera for real-time imaging, with an image processing module to fuse the images and generate high-resolution, high-sensitivity 3D visualization.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If MPI is used for imaging, then sensitivity and 3D imaging capability are improved, but resolution deteriorates
Solution Approach 1:
The patent combines MPI and FMT imaging systems into a unified multimodal imaging platform, integrating the magnetic particle imaging capabilities with fluorescence molecular tomography. This merging allows the system to leverage the high sensitivity and 3D imaging of MPI while compensating for its low resolution through FMT's anatomical structure information, thereby achieving both high sensitivity and high resolution simultaneously.
2Manufacturing precision
If FMT is used for imaging, then anatomical structure information and resolution are improved, but field of view deteriorates
Solution Approach 1:
The patent merges FMT's high-resolution anatomical imaging with MPI's broader field of view capabilities. By integrating the two modalities, the system achieves comprehensive coverage of the entire imaging area while maintaining high resolution through FMT's strengths, thereby resolving the field of view limitation of FMT alone.
Solution Approach 2:
The patent transitions from 2D imaging to 3D volumetric imaging by combining MPI's 3D particle concentration distribution with FMT's 3D fluorescent molecule distribution. This dimensional integration allows the system to achieve both high resolution and extended field of view by reconstructing three-dimensional anatomical and molecular information simultaneously.
3Measurement precision
If MPI and FMT are fused, then detection accuracy and 3D visualization are improved, but device complexity increases
Solution Approach 1:
The patent designs a universal imaging platform that integrates both MPI and FMT modalities within a single system framework. The unified system incorporates common components such as a single animal holder, coordinated control systems, and integrated image processing units that handle both magnetic particle and fluorescent signals, thereby reducing overall system complexity while maintaining multimodal capabilities.
Solution Approach 2:
The patent introduces an intermediary image processing and fusion module that mediates between the MPI and FMT imaging subsystems. This intermediary component coordinates the two modalities, aligns their respective image spaces, and fuses the data to produce integrated 3D visualizations, thereby simplifying the complexity of managing and integrating two separate imaging systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Simultaneously acquires concentration distribution of magnetic nanoparticles and fluorescent molecules, improving detection accuracy and achieving high-resolution visualization of 3D lesion information, integrating anatomical and molecular data for enhanced imaging.
Implementation Method 1
the gradient coil is configured to construct a static field free line (FFL), such that magnetic particles around the FFL are saturated to form a gradient field in a space
Implementation Method 2
the driving coil is configured to counteract a magnetic field of the gradient coil so as to control the FFL to make translational motion
Implementation Method 3
the reception coil is configured to acquire a nonlinear response signal of the magnetic particles
Implementation Method 4
the fluorescence camera is provided directly above the object table to perform real-time imaging of a target object placed on the object table
Data Source
AI summary
A magnetic particle imaging (MPI) and fluorescence molecular tomography (FMT)-fused multimodal imaging system and method for a small animal are provided. The multimodal imaging system includes an image processing module, a display module, a control module, an object table, a gradient coil, a driving coil, a reception coil, a fluorescence camera, and a light source module, where the gradient coil includes a first rounded rectangular coil and a second rounded rectangular coil; the driving coil includes a third rounded rectangular coil, a fourth rounded rectangular coil, and a fifth rounded rectangular coil; and the reception coil is a circular coil.