3D Magnetic Particle Imaging Without Rotating Field-Free Line
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Solution Overview
Problem
Current field-free line (FFL)-type magnetic particle imaging (MPI) techniques require complex mechanical designs and high power consumption for rotating the FFL, leading to increased imaging time and economic costs, despite offering high sensitivity and signal-to-noise ratio (SNR).
Innovation Solution
A three-dimensional (3D) MPI method and system that generates a field-free line without rotation, using a non-uniform mixed-frequency excitation magnetic field to excite magnetic particles and acquire intermodulation response signals, constructing an encoding matrix, and employing an orthogonal magnetic field for line-by-line scanning to achieve 3D imaging.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If FFL-type MPI uses traditional multi-angle rotation methods for spatial encoding, then sensitivity and SNR are improved, but imaging time and device complexity increase significantly
Solution Approach 1:
The patent replaces the mechanical rotation system with a magnetic field-based encoding system. Instead of physically rotating the FFL or using mechanical scanners, the invention uses non-uniform mixed-frequency excitation magnetic fields to encode spatial information along the FFL, eliminating mechanical complexity and reducing imaging time while maintaining high sensitivity and SNR
Solution Approach 2:
The patent changes the excitation magnetic field parameters by applying non-uniform mixed-frequency excitation along the FFL. This allows spatial encoding to be achieved through frequency modulation rather than physical rotation, resolving the contradiction between maintaining high sensitivity and reducing imaging time
2Measurement precision
If FFL-type MPI uses mechanical rotation for spatial encoding, then sensitivity and SNR are improved, but device complexity and manufacturing cost increase
Solution Approach 1:
The patent eliminates the need for mechanical rotation systems by substituting them with a stationary FFL configuration combined with non-uniform mixed-frequency excitation magnetic fields. This substitution removes complex mechanical components while preserving the ability to achieve spatial encoding and maintain high sensitivity
Solution Approach 2:
The patent extracts and removes the mechanical rotation component from the system, keeping only the essential magnetic field generation and detection components. This simplification reduces device complexity and manufacturing cost while maintaining the core functionality of high-sensitivity MPI
3Measurement precision
If FFL-type MPI uses magnetic field rotation for spatial encoding, then sensitivity and SNR are improved, but power consumption increases
Solution Approach 1:
The patent replaces the energy-intensive magnetic field rotation system with a stationary FFL configuration that uses non-uniform mixed-frequency excitation. This substitution eliminates the continuous power requirement for field rotation while maintaining spatial encoding capability and high sensitivity through frequency-based encoding
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach reduces imaging time and manufacturing costs while maintaining high sensitivity and SNR, eliminating the need for complex mechanical rotations and high power consumption, enabling efficient 3D imaging of magnetic particles.
Implementation Method 1
According to the magnetic saturation effect, magnetic nanoparticles at and near the FFR can generate dynamic magnetization response due to the excitation of an alternating magnetic field. In contrast, magnetic nanoparticles far from the FFR are saturated with a strong magnetic field
Implementation Method 2
magnetic nanoparticles at and near the FFR can generate dynamic magnetization response due to the excitation of an alternating magnetic field
Implementation Method 3
applying a non-uniform mixed-frequency excitation magnetic field parallel to the FFL, so as to excite magnetic particles at different positions on the FFL to generate intermodulation response signals
Data Source
AI summary
A three-dimensional (3D) magnetic particle imaging (MPI) method and system without rotating a field-free line (FFL) are disclosed. In accordance with the method, an FFL is generated such that magnetic particles in a region far from the FFL enter a magnetic saturation state. Further, a non-uniform mixed-frequency excitation magnetic field parallel to the FFL is applied to generate intermodulation response signals. In addition, the intermodulation response signals are acquired, amplified and filtered. Moreover, the intermodulation response signals are transmitted to a digital signal processing unit and an image reconstruction unit, and an encoding matrix is constructed. Additionally, a one-dimensional (1D) concentration distribution of the magnetic particles is reconstructed based on the encoding matrix and an actually measured voltage signal. The FFL is driven for line-by-line scanning along a vertical plane of the FFL, thereby achieving 3D imaging.