MRI-Guided Trajectory Guide Frame for DBS Electrode Placement
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Solution Overview
Problem
Current Deep Brain Stimulation (DBS) systems face challenges in achieving optimal clinical efficacy due to the imprecision in locating electrodes within neural tissue, leading to reduced effectiveness in procedures for conditions like Parkinson's disease, as conventional methods are lengthy and have less than optimal outcomes in about 30% of patients.
Innovation Solution
An MRI-guided interventional system with a frame and targeting cannula that allows for precise, localized placement of neuro-modulation leads and other devices, utilizing MRI-visible fiducial markers and user-activatable actuators for accurate positioning and rotation, enabling the use of diagnostic and therapeutic devices within the body.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional stereotactic surgery methods are used for DBS lead placement, then the procedure can be performed with existing equipment, but the placement precision is insufficient and clinical efficacy is reduced
Solution Approach 1:
The patent replaces conventional mechanical stereotactic surgery equipment with an MRI-guided interventional system that uses magnetic field imaging and real-time tracking to achieve precise electrode placement. The system integrates MRI scanning capabilities with interventional tools, allowing visualization and positioning within the magnetic field environment, thereby improving both placement precision and clinical efficacy.
Solution Approach 2:
The patent introduces MRI-visible fiducial markers as intermediary elements that serve as reference points for real-time tracking and positioning. These markers mediate between the MRI imaging system and the interventional tools, enabling continuous monitoring and adjustment during the procedure to achieve accurate electrode placement.
2Productivity
If conventional DBS procedures are performed, then the basic stimulation function is achieved, but the procedure duration is long and efficacy is reduced in about 30% of patients
Solution Approach 1:
The patent enables continuous monitoring and adjustment during the entire procedure through real-time MRI imaging. The system allows uninterrupted visualization and tracking of the electrode placement process, eliminating the need for separate preoperative and intraoperative imaging sessions, thereby reducing overall procedure time while maintaining high precision.
Solution Approach 2:
The patent implements a dynamic positioning system that can adjust the trajectory and position of interventional tools in real-time based on live MRI feedback. This dynamic capability allows for immediate correction of placement deviations and adapts to anatomical variations, reducing the time required for trial placements and revisions.
3Manufacturing precision
If MRI-guided interventional systems are used, then placement precision and clinical efficacy are improved, but the device complexity increases
Solution Approach 1:
The patent designs the MRI-guided interventional system to perform multiple functions within a single integrated platform. The system combines MRI scanning, real-time imaging, tracking, and interventional tool guidance in one unified system, eliminating the need for separate equipment and reducing overall system complexity despite the advanced capabilities.
Solution Approach 2:
The patent integrates multiple functional components within a nested structure, where interventional tools can be inserted through the MRI scanner bore and positioned within the patient's body while remaining visible and trackable in the MRI field. This nested arrangement allows compact integration of imaging and intervention capabilities without requiring separate rooms or equipment.
Data Source
AI summary
An MRI-guided interventional system includes a trajectory guide frame for guiding an interventional device with respect to a patient in an MRI-guided procedure and including a base, a platform, a targeting cannula, and a stabilizer mechanism. The platform is mounted on the base and includes a support table and a moving plate that is translatable relative to the support table and the base along a translational axis. The targeting cannula is mounted on the moving plate for movement therewith and includes an elongate guide bore defining a trajectory axis. The stabilizer mechanism is operable to selectively control movement between the support table and the moving plate to stabilize a position of the targeting cannula with respect to the base. The frame is operable to translate the moving plate along the translational axis relative to the base to position the trajectory axis. The translational axis is transverse to the trajectory axis.