MRI Sequence Control Circuitry for Multi-Slice CEST Imaging
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Solution Overview
Problem
Magnetic Resonance Imaging (MRI) using the CEST method is time-consuming due to the need for repetitive MT pulses and prolonged data acquisition times, especially when acquiring CEST spectra for multiple slices.
Innovation Solution
Implementing a magnetic resonance imaging apparatus with sequence control circuitry that performs multi-slice simultaneous data acquisition, applying MT pulses of varying frequencies under a gradient magnetic field to saturate protons across multiple slices, thereby shortening imaging time and enhancing the CEST effect.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of time
If conventional CEST pulse sequence is used to acquire data for multiple slices sequentially, then measurement precision of CEST effect is maintained, but imaging time becomes excessively long
Solution Approach 1:
The patent divides the imaging space into multiple slices and applies MT pulses to each slice independently and simultaneously. By segmenting the data acquisition process into parallel slice-specific acquisitions rather than sequential processing, the system reduces total imaging time while maintaining CEST measurement precision for each individual slice
Solution Approach 2:
The patent introduces parallel processing across the slice dimension, transforming the conventional sequential single-slice acquisition into multi-slice simultaneous acquisition. This dimensional expansion allows multiple data sets to be collected in parallel, dramatically improving productivity without sacrificing measurement quality
2Productivity
If MT pulses are applied to multiple slices simultaneously, then imaging time is reduced, but device complexity increases
Solution Approach 1:
The patent employs dynamic frequency modulation of MT pulses across different slices, where each slice receives MT pulses at frequencies offset by the slice selection gradient. This dynamic approach allows simultaneous multi-slice excitation while maintaining frequency selectivity, achieving high productivity without requiring overly complex hardware modifications
Solution Approach 2:
The system changes the frequency parameter of MT pulses in conjunction with slice position, using gradient magnetic fields to create frequency encoding across slices. By varying the frequency parameter systematically across slices, the patent enables parallel acquisition with manageable sequence control complexity
3Device complexity
If conventional sequential slice acquisition is used, then sequence control is simple, but imaging time becomes unacceptably long
Solution Approach 1:
The patent merges multiple slice acquisitions into a single simultaneous imaging sequence by combining MT pulse application across all slices with parallel data acquisition. This consolidation eliminates the need for sequential processing while maintaining relatively simple sequence control through systematic frequency modulation, achieving fast imaging without excessive complexity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach significantly reduces imaging time while improving image quality by simultaneously acquiring MT effects across multiple slices, enhancing the CEST effect and reducing the number of data acquisition points needed.
Implementation Method 1
Magnetic resonance imaging apparatus and magnetic resonance imaging method
Implementation Method 2
MT (Magnetization Transfer) pulses corresponding to the resonance frequency of non-free protons are applied as saturation pulses
Data Source
AI summary
A magnetic resonance imaging apparatus according to an embodiment includes sequence control circuitry. The sequence control circuitry applies an MT (Magnetization Transfer) pulse over a plurality of slices under a gradient magnetic field and configured to apply, for each of the plurality of slices to which the MT pulse is applied, an RF pulse having a frequency corresponding to a resonance frequency of certain protons in each of the plurality of slices.