MRI-Visible Trajectory Guides for Precise Biomedical Delivery
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Solution Overview
Problem
Current biomedical applications face challenges in delivering therapeutic agents precisely to specific locations within the body, particularly in areas protected by the blood-brain barrier, such as the brain and spinal cord, due to a lack of effective targeting systems that minimize damage to surrounding tissues.
Innovation Solution
The use of MRI-assisted targeting methods involving adjustable turrets and trajectory guides with MRI-visible styles to determine and adjust the trajectory of delivery devices, allowing for precise targeting and delivery of therapeutic agents or electrical currents to desired areas while avoiding obstacles.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If microinjections are performed into the brain parenchyma to deliver therapeutic agents, then therapeutic delivery to the target site is achieved, but damage to surrounding brain structures occurs
Solution Approach 1:
The patent applies preliminary action by performing MRI imaging and trajectory planning before the actual therapeutic injection. The system pre-determines the optimal injection path and depth, allowing the healthcare provider to visualize the exact trajectory and avoid surrounding structures during the subsequent therapeutic delivery step.
Solution Approach 2:
The patent implements feedback through MRI imaging that allows real-time or pre-procedural visualization of the needle trajectory relative to brain structures. The system provides visual feedback to the operator, enabling adjustment of the injection path to achieve precise targeting while avoiding damage to surrounding tissues.
2Manufacturing precision
If precise targeting systems are implemented to deliver therapeutic agents to specific brain locations, then treatment effectiveness is improved, but device complexity increases
Solution Approach 1:
The patent uses MRI imaging as an intermediary between the healthcare provider and the brain target site. The MRI system serves as a mediator that provides visual information about brain structures and needle trajectory, enabling precise targeting without requiring the injection device itself to be highly complex. The MRI scanner acts as the intermediary that bridges the gap between the simple injection device and the complex anatomical target.
3Ease of operation
If therapeutic delivery is performed without precise targeting, then device simplicity is maintained, but treatment effectiveness decreases due to residual damage to surrounding structures
Solution Approach 1:
The MRI imaging system serves as an intermediary that adds precision to an otherwise simple injection procedure. The healthcare provider can maintain a relatively simple injection device while the MRI scanner provides the necessary guidance and visualization to ensure treatment effectiveness and minimize damage to surrounding structures.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables precise and minimally invasive delivery of therapeutic agents and electrical currents to targeted areas, enhancing the effectiveness of treatments for neurological disorders and other conditions by reducing damage to surrounding tissues.
Implementation Method 1
visualizing the MRI-visible style using an MRI imager; determining the trajectory of the channel based on the visualizing
Data Source
AI summary
The present disclosure provides methods for targeting a biomedical system. Aspects of the subject methods include determining the trajectory of a targeting device using magnetic resonance imaging (MRI) of a MRI-visible style of a trajectory guide that is compatible with the targeting device. Targeted biomedical systems may be utilized for a variety of purposes including targeted delivery of a therapeutic, holding a therapeutic device, positioning of a therapeutic device and other uses. Also provided are devices and systems that can be used in practicing the described methods including but not limited to trajectory guides and adjustable targeting systems, as well as non-transitory computer readable medium storing instructions that, when executed by a computing device, cause a computing device to perform steps of the described methods.