Mesenchymal Stem Cell Formulation for Viable Nonsurgical Skin Rejuvenation
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Solution Overview
Problem
Current treatments for facial wrinkles and skin aging, such as dermal fillers and autologous fat injections, have temporary effects and significant side effects, while autologous fibroblast injections require surgical procedures, and there is a need for a more natural and effective anti-aging solution.
Innovation Solution
A mesenchymal stem cell (MSC) formulation using a balanced salt solution, anticoagulant, and human serum albumin to maintain MSC viability and function, allowing local administration to the skin without surgery, with the ability to secrete collagen and reduce oxidative stress.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If dermal fillers are injected to correct facial wrinkles, then wrinkle filling effect is improved, but side effects such as bruising, swelling, pain, infections, lumps, and allergic reactions increase
Solution Approach 1:
The patent uses mesenchymal stem cells as an intermediary biological agent that naturally integrates with skin tissue to provide wrinkle filling effects. Unlike synthetic fillers that directly fill space, MSCs act as living cells that secrete extracellular matrix and collagen, providing a more natural and biocompatible solution that reduces allergic reactions and inflammatory responses while maintaining wrinkle correction efficacy
2Duration of action of moving object
If autologous fat or fibroblasts are injected for sustained therapeutic effect, then duration of action is improved, but surgical procedures are required increasing device complexity
Solution Approach 1:
The patent extracts and isolates mesenchymal stem cells from autologous sources (such as adipose tissue or bone marrow) in a controlled laboratory setting, then delivers them via simple injection procedures. This separates the complex cell isolation step from the administration step, allowing sustained therapeutic effects through autologous cells while eliminating the need for complex surgical procedures during treatment delivery
3Loss of time
If MSC formulation is stored for extended period, then availability for delivery is improved, but cell viability and function decrease
Solution Approach 1:
The patent optimizes storage conditions by controlling temperature parameters (refrigerated or frozen storage), adjusting solvent composition (using balanced salt solutions with anticoagulants and proteins), and controlling cell density. These parameter changes create an optimal storage environment that maintains MSC viability and functional capacity for extended periods, enabling proper storage and delivery timing while preserving cell therapeutic potential
Data Source
AI summary
The invention provides compositions of a mesenchymal stem cells (MSC) formulation, a characterization method to define the potency of MSC for cosmetic purposes and use of the MSC product to ameliorate the skin wrinkles, reduce the signs of aging attenuate skin scar or treat hair loss. Practicing these methods and MSC formulation application will greatly improve the quality and appearance of the skin.