Multi-spectral physiologic visualization for blood flow quantification
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Solution Overview
Problem
Conventional laser-based perfusion technologies face inaccuracies due to motion artifacts in tissues and organs, especially in clinical scenarios where the target is moving, such as a beating heart, and struggle to penetrate deep enough to provide accurate blood flow and perfusion measurements.
Innovation Solution
A multispectral imaging system using multiple light sources with different wavelengths (e.g., visible and near-infrared) to penetrate varying depths, combining anatomical and physiological information to account for motion artifacts and enhance visualization and quantification of blood flow and perfusion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional laser-based perfusion technologies are used, then blood flow and perfusion can be visualized, but motion artifacts disrupt measurement accuracy in moving tissues and organs
Solution Approach 1:
The patent changes the wavelength parameter of light to penetrate different tissue depths. By using multiple wavelengths (e.g., 785 nm for superficial, 1064 nm for deeper penetration), the system captures blood flow information from different depths, allowing differentiation between motion artifacts and actual perfusion changes through depth-resolved measurements
Solution Approach 2:
The patent adds the depth dimension to traditional planar perfusion imaging. By implementing optical coherence tomography (OCT) based multi-spectral physiologic visualization, the system creates three-dimensional blood flow maps that resolve perfusion information along the depth axis, enabling distinction between surface motion artifacts and subsurface perfusion changes
2Illumination intensity
If light of shorter wavelengths is used, then detailed anatomic visualization of tissue surface is achieved, but penetration depth into sub-surface layers is insufficient
Solution Approach 1:
The patent segments the imaging function into multiple wavelength channels, each optimized for specific depth ranges. Shorter wavelengths (e.g., 785 nm) capture superficial anatomic details and capillary perfusion, while longer wavelengths (e.g., 1064 nm, 1310 nm) penetrate deeper to visualize larger vessels and subsurface perfusion, with each channel processed and displayed separately or combined
Solution Approach 2:
The patent creates a multi-functional imaging system that simultaneously performs anatomic visualization and physiologic perfusion measurement across multiple depth layers. The same optical platform and camera system process multiple wavelengths to generate both structural images and functional blood flow maps from different tissue depths
3Length of stationary object
If light of longer wavelengths is used, then penetration depth into sub-surface layers is improved, but detailed anatomic visualization capability is reduced
Solution Approach 1:
The patent segments the imaging function into multiple wavelength channels, each optimized for specific depth ranges. Shorter wavelengths (e.g., 785 nm) capture superficial anatomic details and capillary perfusion, while longer wavelengths (e.g., 1064 nm, 1310 nm) penetrate deeper to visualize larger vessels and subsurface perfusion, with each channel processed and displayed separately or combined
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system provides accurate and real-time visualization and quantification of blood flow and perfusion by combining anatomical structure and physiological data, reducing motion artifacts and improving image quality and accuracy in clinical applications.
Implementation Method 1
light at the second wavelength is configured to penetrate the sample to a first depth and provide information related to the sample to the camera; and light at least the third wavelength is configured to penetrate the sample to a second depth different from the first depth
Implementation Method 2
a camera configured to receive information related to the first, second and at least third light sources from the sample
Data Source
AI summary
Multispectral imaging systems are provided including a first light source having a first wavelength configured to image a sample; a second light source, different from the first light source, having a second wavelength, different from the first wavelength, configured to image the sample; and at least a third light source, different from the first and second light sources, having a third wavelength, different from the first and second wavelengths, configured to image the sample. A camera is configured to receive information related to the first, second and at least third light sources from the sample. A processor is configured to combine the information related to the first, second and at least third light sources provided by the camera to image an anatomical structure of the sample, image physiology of blood flow and perfusion of the sample and/or synthesize the anatomical structure and the physiology of blood flow and perfusion of the sample in terms of a blood flow rate distribution. The imaging system is directed and focused on a field of view (FOV) in a region of interest of the sample using an endoscope.