MUC1 Receptor Activation for Stem Cell Proliferation

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Solution Overview

Problem

Current methods fail to effectively stimulate the proliferation of MUC1-expressing cells, particularly stem cells and progenitor cells, which is crucial for various therapeutic and research applications, as existing technologies do not adequately activate the MUC1 receptor to promote cell growth and expansion.

Innovation Solution

Activating the MUC1 receptor by using agents that multimerize the MGFR portion, increase the cleavage of MUC1 to the growth factor receptor form, or bind ligands that activate the MGFR portion, thereby stimulating cell proliferation in non-tumorous cells such as stem cells, progenitor cells, and neutrophils.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If existing technologies are used to stimulate cell proliferation, then cell growth can be achieved, but the stimulation effectiveness is insufficient and cell expansion is limited

Engineering Contradiction:

Improvecell proliferation rateVSAvoidstimulation effectiveness

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The patent changes the molecular state of the MUC1 receptor by inducing cleavage to generate MGFR, and by multimerizing MGFR to activate signaling pathways. This parameter change from inactive to active receptor state dramatically enhances cell proliferation stimulation effectiveness, resolving the contradiction between limited expansion and stimulation effectiveness

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent uses MGFR as an intermediary between the MUC1 receptor and downstream signaling pathways. By generating and multimerizing MGFR, the patent creates an effective mediator that transmits growth signals to proliferate MUC1-expressing cells, thereby improving both stimulation effectiveness and proliferation rate

Inventive Principle:

Principle #24Intermediary (Mediator)

2Productivity

If MUC1 receptor is activated to promote cell growth, then cell expansion is enhanced, but the method complexity increases due to requiring cleavage agents and multimerizing agents

Engineering Contradiction:

Improvecell expansionVSAvoidmethod complexity

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The patent segments the MUC1 receptor into distinct functional components by inducing cleavage to generate MGFR. This segmentation allows the active proliferative signaling function to be separated from the full-length receptor, enabling targeted activation through multimerizing agents that specifically bind MGFR, thus enhancing cell expansion while managing method complexity through focused molecular targeting

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The patent extracts the MGFR component from the full-length MUC1 receptor through controlled cleavage. By taking out and isolating the MGFR segment, the patent enables specific multimerization and activation of only the proliferative signaling portion, improving cell expansion effectiveness while reducing off-target effects and simplifying the activation mechanism

Inventive Principle:

Principle #2Taking out (Extraction)

Data Source

PatentUS8859495B2Methods for stimulating or enhancing proliferation of non-tumorous cells expressing MUC1 receptors

Publication Date: 2014.10.14 MINERVA BIOTECHNOLOGIES CORP

AI summary

The present application discloses a method for stimulating or enhancing proliferation of a population of cells by activating MUC1 receptor on the cells.