Mucoadhesive Soluble Patch for Sustained Oral Analgesic Delivery
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Solution Overview
Problem
Current treatments for aphthous stomatitis, such as analgesic gels and oral patches, are either ineffective, difficult to apply, or require removal after analgesic effect, leading to pain and inconvenience, and lack long-lasting pain relief for painful oral disorders.
Innovation Solution
Development of a mucoadhesive patch with a soluble alginate film loaded with mesoporous silica microparticles containing lidocaine hydrochloride, which adheres to the oral mucosa, providing rapid and sustained pain relief without the need for removal, suitable for both adults and children.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If analgesic gels are used for pain relief, then pain relief is achieved, but the treatment is difficult to apply and does not provide long-lasting effects
Solution Approach 1:
The patent uses a thin film matrix as the delivery vehicle for the analgesic agent. This film can be applied directly to the affected area and provides sustained release of the active ingredient over time, combining ease of application with prolonged therapeutic effect.
Solution Approach 2:
The analgesic agent is pre-loaded into the film matrix during manufacturing, so that upon application, the drug is already positioned at the site of action and begins immediate sustained release, eliminating the need for repeated applications.
2Duration of action of moving object
If oral patches are used to deliver analgesics, then pain relief is provided, but the patches require removal after the analgesic effect is achieved, which is inconvenient and could be painful
Solution Approach 1:
The film is designed to be temporary and disposable, providing its analgesic effect over a specific period and then naturally detaching or dissolving without requiring active removal by the patient, thus maintaining convenience while providing sustained relief.
Solution Approach 2:
The film automatically detaches or dissolves after delivering its therapeutic payload, eliminating the need for patient intervention to remove it. The system serves itself by completing the entire cycle from application to disposal without user action beyond the initial placement.
3Reliability
If high doses of analgesics are used, then pain relief is enhanced, but side effects such as numbing of other areas and throat/speech/swallowing problems increase
Solution Approach 1:
The film delivers the analgesic agent locally to the specific affected area rather than systemically. This localized delivery ensures high concentration where needed for effective pain relief while minimizing exposure and side effects in other body regions.
Solution Approach 2:
The film matrix contains porous structures that control the release rate of the analgesic agent, allowing sustained delivery at therapeutic concentrations without requiring high total doses, thereby reducing the risk of systemic side effects.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The patch effectively relieves pain for up to 90 minutes, is easy to apply, and minimizes side effects, offering a convenient and effective solution for managing aphthous stomatitis and other oral pain conditions.
Implementation Method 1
mucoadhesive patch comprising a pharmaceutically acceptable soluble film and mesoporous microparticles loaded with an analgesic (e.g. local or topical anaesthetic) agent
Implementation Method 2
mesoporous microparticles loaded with an analgesic (e.g. local or topical anaesthetic) agent
Data Source
AI summary
The present invention relates to therapeutic patches, particularly to soluble patches that adhere to mucosal membranes (e.g. in the oral cavity) to deliver analgesic (e.g. local anaesthetic) compounds (e.g. lidocaine) to sites of pain. In particular, the invention provides a mucoadhesive patch comprising a pharmaceutically acceptable soluble film and mesoporous microparticles loaded with an analgesic agent.