Nutraceutical Composition Using Mucosal Delivery for Veisalgia

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Solution Overview

Problem

Existing delivery systems for preventing and mitigating veisalgia are ineffective due to issues with solubility, palatability, and potency, particularly in the state of nausea and impaired metabolism, and fail to adequately support liver and end organ metabolism.

Innovation Solution

A nutraceutical composition is administered via alternative delivery routes such as buccal, nasal, respiratory, rectal, and dermal absorption, bypassing the digestive system, to support liver and end organ metabolism with lower concentrations and dosages, including flavonoids, antioxidants, vitamins, minerals, and anti-inflammatory agents.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of operation

If ingestion delivery system is used to administer nutraceuticals, then the system can deliver compounds to the body, but nausea and dysphagia prevent compliance with dosage regimen

Engineering Contradiction:

Improvecompliance with dosage regimenVSAvoidnausea and dysphagia

Core Design Contradiction:

Ease of operationVSObject-affected harmful factors

Solution Approach 1:

The patent uses alternative delivery routes (buccal, sublingual, nasal, rectal, dermal) as intermediaries to bypass the gastrointestinal tract. These routes serve as mediators that deliver nutraceuticals directly to the bloodstream without requiring ingestion, thus avoiding the harmful effects of nausea and dysphagia while maintaining effective drug delivery.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent segments the delivery system into multiple alternative routes rather than relying on a single ingestion pathway. By dividing the delivery approach into buccal, sublingual, nasal, rectal, and dermal options, the system allows patients to choose a route that does not trigger nausea or dysphagia, thereby improving compliance.

Inventive Principle:

Principle #1Segmentation

2Quantity of substance

If large liquid dosage is required for ingestion delivery, then adequate dosage can be administered, but TSA restrictions on liquid transport impede compliance during flights

Engineering Contradiction:

Improvedosage amountVSAvoidportability during travel

Core Design Contradiction:

Quantity of substanceVSAdaptability or versatility

Solution Approach 1:

The patent changes the physical form and delivery parameters of the nutraceuticals from large liquid volumes to concentrated forms suitable for alternative delivery routes. This allows the same therapeutic dosage to be delivered in much smaller, travel-friendly quantities that comply with TSA restrictions while maintaining adequate treatment levels.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent transitions from oral liquid delivery to multiple alternative dimensions of administration including buccal, sublingual, nasal, rectal, and dermal routes. This dimensional shift enables portable, travel-compliant delivery systems that can provide adequate dosages without requiring large liquid volumes.

Inventive Principle:

Principle #17Another dimension (Dimensionality change)

3Reliability

If prior art delivery systems are used, then some nutraceutical delivery is achieved, but solubility, palatability, and potency issues reduce effectiveness

Engineering Contradiction:

Improveeffectiveness of veisalgia preventionVSAvoidsolubility and palatability

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent employs alternative delivery routes as intermediaries that bypass the complex issues of solubility and palatability associated with oral ingestion. These routes provide direct access to the bloodstream, ensuring reliable effectiveness without being constrained by manufacturing challenges related to solubility and taste.

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively prevents and mitigates veisalgia by directly enriching the bloodstream with nutraceuticals, neutralizing alcohol toxins, and supporting metabolic functions, even in the presence of nausea and impaired digestion.

Implementation Method 1

administering to an individual a therapeutically effective amount of a nutraceutical composition... via alternative delivery routes such as buccal, nasal, respiratory, rectal, and dermal absorption

Methodology Applied

Scientific EffectAbsorption: Absorption (physical)

Data Source

PatentUS12576045B2Methods and nutraceutical compositions for the prevention and/or mitigation of veisalgia

Publication Date: 2026.03.17 H PROOF LLC

AI summary

Nutraceutical compositions and the methods for preventing and/or mitigating veisalgia by the administration thereof. The nutraceutical compositions address the challenged state of the individual and potentiate their ability to be compliant with treatment when the metabolic functions of the liver are overwhelmed as alcohol metabolism depletes hepatic supplies of needed molecules. The methods provide the nutraceutical composition directly to the end organs where alcohol and toxin infused blood is also metabolized and neutralized.