Mucosal Protective Film via Aloe Vera Hyaluronic Acid Honey Composition

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Solution Overview

Problem

Current treatments for gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux often have side effects and are ineffective in reducing symptoms and promoting tissue healing in the mucosa of the esophagus and pharynx, and there is a lack of effective solutions for lesions and mucositis in the oral and pharyngo-laryngo-esophageal tract.

Innovation Solution

A composition comprising Aloe vera gel, hyaluronic acid, and honey, optionally with chondroitin sulphate, which forms a protective film on the mucosa, reducing inflammation and promoting tissue repair without the side effects of existing treatments.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional drugs (PPIs, antacids, alginate-based drugs) are administered for GERD treatment, then acid production is inhibited or symptoms are relieved, but side effects occur including intestinal issues, skin eruptions, heart palpitations, and increased osteoporosis risk

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses natural, biodegradable substances (Aloe vera, hyaluronic acid, honey, chondroitin sulphate) that are metabolized and eliminated by the body without accumulating, replacing long-term pharmaceutical interventions with short-acting natural remedies that leave no harmful residues

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The composition acts as an intermediary protective layer between gastric acid and the mucosa, using substances like hyaluronic acid and chondroitin sulphate that form a physical barrier and mediate the interaction between acid and tissue, preventing direct damage without systemically inhibiting acid production

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If Aloe vera and honey mixture is used, then some protective effect is achieved, but film-forming and mucoadhesive properties are insufficient compared to the invention

Engineering Contradiction:

Improveprotective effectVSAvoidcomposition complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines four distinct natural substances (Aloe vera, hyaluronic acid, honey, chondroitin sulphate) into a composite formulation where each component contributes specific properties: Aloe vera provides soothing effects, hyaluronic acid provides film-forming and mucoadhesive properties, honey provides antimicrobial and healing properties, and chondroitin sulphate provides additional protective and regenerative effects

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent merges multiple therapeutic functions into a single composition by combining substances with complementary properties, creating a synergistic effect where the whole is greater than the sum of its parts, achieving superior film-forming and mucoadhesive properties compared to simple mixtures

Inventive Principle:

Principle #5Merging (Combining)

3Reliability

If proton pump inhibitors are used for long-term treatment, then acid production is considerably inhibited, but osteoporosis and bone fragility increase

Engineering Contradiction:

Improveacid inhibitionVSAvoidbone strength

Core Design Contradiction:

ReliabilityVSStrength

Solution Approach 1:

The composition enables the mucosa to heal itself by providing protective films and creating favorable conditions for natural regeneration, allowing the body's own repair mechanisms to function without systemic acid suppression that disrupts calcium metabolism and bone health

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

The patent converts the harmful effect of acid exposure into a beneficial healing process by using controlled acidic environments that stimulate mucosal regeneration while protecting vulnerable areas, transforming the pathogenic role of acid into a physiologic stimulus for repair

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition effectively reduces symptoms of GERD and laryngopharyngeal reflux, promotes tissue re-epithelization, and protects the mucosa from acidic and basic vapors, providing a rapid and effective treatment with minimal side effects.

Implementation Method 1

liquid composition (C) according to the invention... endowed with the following properties: Hydrating, moistening, lubricating, viscosity enhancing, film-forming and protective

Methodology Applied

Scientific EffectFilm-forming:

Implementation Method 2

liquid composition (C) according to the invention... endowed with the following properties: Hydrating, moistening, lubricating, viscosity enhancing, film-forming and protective, with a barrier effect due to the formation of a viscous layer that coats the esophageal mucosa by adhering to it

Methodology Applied

Scientific EffectMucoadhesive:

Implementation Method 3

liquid composition (C) according to the invention... performs an anti-inflammatory action, promotes the process of tissue re-epithelisation and cicatrisation against lesions

Methodology Applied

Scientific EffectTissue re-epithelization:

Implementation Method 4

liquid composition (C) according to the invention... performs an anti-inflammatory action, promotes the process of tissue re-epithelisation and cicatrisation

Methodology Applied

Scientific EffectAnti-inflammatory action:

Implementation Method 5

Methodology Applied

Scientific EffectBarrier effect:

Data Source

PatentEP3773615B1Liquid composition for use in the treatment of the mucosa of the oro-pharyngo-laryngo-esophageal tract

Publication Date: 2023.07.05 SOFAR SWISS

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AI summary

The present invention relates to an aqueous liquid composition or hydroalcoholic liquid comprising a mixture which comprises or, alternatively, consists of a combination of Aloe vera gel, hyaluronic acid and honey and, optionally, food and/or pharmaceutical grade additives and/or technological excipients; said composition being for use in the preventive and/or curative treatment of the symptoms and disorders associated with gastroesophageal reflux (GERD) and/or laryngopharyngeal reflux (RLF) and the disease caused thereby, for use as an adjuvant in the symptomatic treatment of gastroesophageal and/or laryngopharyngeal reflux disease, or for use in a preventive and/or curative treatment against: (i) lesions of the oral cavity and of the pharyngo-laryngo-esophageal tract; (ii) mucositis; and/or (iii) aphthae and/or aphthoid lesions.