Mulberry Extract With-Meal Dosing for Postprandial Glucose Control
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current treatments for managing postprandial glucose response in diabetic and prediabetic individuals are limited by gastrointestinal side effects and lack of effective nutritional solutions that can be easily integrated into daily meals.
Innovation Solution
Administering a mulberry leaf extract as a powder or granulate with a balanced meal, containing 1-deoxynojirimycin (DNJ), to reduce postprandial glucose levels by inhibiting alpha-glucosidase activity and delaying carbohydrate digestion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional treatments for managing postprandial glucose are used, then glucose control is achieved, but gastrointestinal side effects occur
Solution Approach 1:
The patent changes the administration timing parameter from pre-meal to with-meal, and modifies the formulation parameters (powder/granulate form, concentration of active compounds) to achieve effective glucose control without gastrointestinal side effects. This resolves the contradiction by adjusting parameters to maintain effectiveness while eliminating harmful effects.
2Reliability
If pre-meal administration of mulberry extract is used, then postprandial glucose levels are reduced, but consumer compliance decreases due to inconvenience
Solution Approach 1:
The patent inverts the conventional administration timing from pre-meal to with-meal. This inversion makes the supplement more convenient for consumers to integrate into their daily routine, improving compliance while maintaining the glucose-lowering effect. The active compounds are released in the intestine during meal consumption, achieving the same therapeutic effect with better ease of operation.
3Ease of operation
If mulberry extract is administered with a meal, then ease of operation improves, but the mechanism of action must be optimized for intestinal release
Solution Approach 1:
The patent modifies formulation parameters including particle size, concentration of active compounds (1-deoxynojirimycin, fagomine, GABA), and excipient selection to enable controlled intestinal release. These parameter changes allow the simple with-meal administration to effectively deliver active compounds to the intestine, maintaining ease of operation while managing formulation complexity through scientific optimization.
Data Source
AI summary
A method for reducing postprandial glucose from a balanced meal includes orally administering to an individual a composition containing mulberry extract together with the meal. The postprandial glucose is reduced relative to postprandial glucose from administering a corresponding composition comprising mulberry extract before subsequent administration of the balanced meal.