Multi-analyte Reference Solution for Blood Analyzer Calibration
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Solution Overview
Problem
Existing reference solutions for calibrating blood analyzers that measure hematocrit and biological analytes simultaneously are ineffective due to high concentrations of conductivity-reducing additives, leading to increased costs, interference with other analytes, and stability issues, requiring separate solutions for accurate calibration.
Innovation Solution
A reference solution comprising a combination of water-soluble polymers, glycols, and polysaccharides, such as polyethylene glycol, ethylene glycol, and dextran, that maintains conductivity representative of known hematocrit levels without causing viscosity or precipitation, allowing for simultaneous calibration of hematocrit and biological analytes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If high concentrations of conductivity-reducing additives are used to achieve representative conductivity, then the conductivity matches hematocrit levels, but the cost increases and interference with other analytes occurs
Solution Approach 1:
The patent changes the chemical composition parameters by using specific combinations of polymers, glycols, and polysaccharides in controlled concentrations to achieve the desired conductivity without the harmful effects of traditional additives. This allows precise control over conductivity while minimizing interference with other analyte measurements.
Solution Approach 2:
The patent employs composite reference solutions combining multiple components (polymers, glycols, polysaccharides) in specific ratios to create a reference solution that simultaneously achieves accurate conductivity representation and minimal analytical interference. This composite approach allows the solution to fulfill multiple functions without compromising measurement accuracy.
2Measurement precision
If high concentrations of additives are used to reduce conductivity, then conductivity matches blood, but viscosity increases and precipitation occurs
Solution Approach 1:
The patent optimizes the concentration parameters of individual components to achieve the target conductivity at lower overall additive concentrations than traditional methods. By carefully adjusting the parameters of polymer, glycol, and polysaccharide concentrations, the solution maintains stability and avoids precipitation while still representing blood conductivity accurately.
Solution Approach 2:
The patent creates a simplified model system using synthetic polymers and glycols that copies the essential conductivity characteristics of blood without replicating its complexity. This model approach allows the reference solution to represent blood conductivity without suffering from the stability issues of actual blood products or high-concentration additive solutions.
3Measurement precision
If separate reference solutions are used for hematocrit and biological analytes, then accurate calibration is achieved, but the overall speed decreases and cost increases
Solution Approach 1:
The patent merges the functions of separate reference solutions into a single multi-functional reference solution that simultaneously provides accurate hematocrit calibration through conductivity matching and biological analyte calibration through known analyte concentrations. This consolidation allows both calibrations to be performed in a single step, improving speed while maintaining accuracy.
Solution Approach 2:
The patent designs a universal reference solution that serves multiple purposes: it calibrates both hematocrit measurements (via conductivity representation) and biological analyte measurements (via known analyte concentrations). This multi-functional approach eliminates the need for separate reference solutions, thereby increasing productivity without sacrificing calibration accuracy for either parameter.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution provides a stable, non-viscous reference solution that effectively calibrates blood analyzers for hematocrit and biological analytes, reducing costs and interference, while maintaining accurate conductivity and analyte concentrations, thus improving the efficiency and accuracy of blood analysis.
Implementation Method 1
a reference solution for use in instruments that determine hematocrit levels in biological samples by measuring the conductivity of the biological samples
Data Source
AI summary
The present invention provides a reference solution for use in instruments that determine hematocrit levels in biological samples by measuring the resistance and/or conductivity of the biological samples. A reference solution according to the invention achieves conductivities representative of known hematocrit levels in blood, while maintaining tolerable levels of interference with the measurement of other analytes in the reference solution.