Multi-Analyte Sensor Membrane for Simultaneous Selective Monitoring
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Solution Overview
Problem
Existing biosensors face challenges in simultaneously monitoring multiple analytes with high sensitivity and accuracy, requiring complex manufacturing processes due to the need for separate semi-permeable membranes on different analyte electrodes.
Innovation Solution
A multi-analyte monitoring sensor with a polymer membrane layer permeable to multiple analytes, covering enzyme layers on working electrodes, simplifying the manufacturing process while maintaining sensitivity and accuracy by allowing simultaneous permeation of different analytes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If separate semi-permeable membranes are coated on different analyte electrodes, then selectivity for each analyte is improved, but manufacturing complexity and precision requirements increase significantly
Solution Approach 1:
The patent merges multiple separate semi-permeable membrane functions into a single polymer membrane layer that covers all working electrodes. This polymer membrane is designed to be permeable to multiple analytes simultaneously, eliminating the need for separate membranes on each electrode and significantly simplifying the manufacturing process while maintaining analyte detection capability
Solution Approach 2:
The polymer membrane layer serves multiple functions simultaneously: it acts as a semi-permeable barrier for multiple different analytes, provides mechanical support, and enables selective permeation across all working electrodes. This multi-functional design replaces what would otherwise require multiple specialized components
2Manufacturing precision
If separate semi-permeable membranes are used for each analyte electrode, then analyte permeation control is improved, but manufacturing precision requirements become extremely high
Solution Approach 1:
By combining multiple membrane functions into a single polymer membrane layer, the patent reduces the number of coating operations from multiple separate coatings to one unified coating process. This dramatically lowers the cumulative precision requirements while ensuring uniform coverage across all electrodes
3Ease of manufacture
If a single polymer membrane layer permeable to multiple analytes is used, then manufacturing process is simplified, but selectivity control for each analyte may be compromised
Solution Approach 1:
The patent optimizes the polymer membrane's physical and chemical parameters (such as porosity, molecular weight cutoff, and polymer composition) to achieve appropriate permeability for multiple analytes of different sizes and properties. By carefully controlling these parameters, the membrane provides sufficient selectivity while maintaining ease of manufacture
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sensor achieves high sensitivity and accuracy in monitoring multiple analytes with a simplified manufacturing process, enhancing stability and reducing interference between electrodes.
Implementation Method 1
The polymer membrane layer is permeable to the first analyte and the second analyte and covers the first analyte enzyme layer and the second analyte enzyme layer
Implementation Method 2
the polymer membrane layer can simultaneously permeate the two analytes
Data Source
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AI summary
The present disclosure describes a multi-analyte monitoring sensor, which includes a working electrode, an enzyme sensing layer set on the working electrode, and a polymer membrane layer. The working electrode comprises a first working electrode and a second working electrode; the enzyme sensing layer comprises a first analyte enzyme layer and a second analyte enzyme layer, with the first analyte enzyme layer set on the first working electrode and the second analyte enzyme layer set on the second working electrode, and the second analyte being different from the first analyte; the polymer membrane layer is permeable to the first analyte and the second analyte and covers the first analyte enzyme layer and the second analyte enzyme layer. Thus, a multi-analyte monitoring sensor capable of simultaneously monitoring multiple analytes can be provided.