Multi-analyte Sensor Temporal Signal Deconvolution
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Solution Overview
Problem
Current implantable sensors are unable to detect multiple analytes simultaneously due to challenges in deconvoluting signals and incompatibility of polymer scaffolds for different luminescent sensing compounds, limiting their effectiveness in monitoring various biological analytes.
Innovation Solution
Development of multi-analyte sensors using carefully selected polymer-luminescent sensing compound combinations that emit temporally distinguishable signals, allowing for the simultaneous detection of multiple analytes by altering the luminescent output and lifetime of the sensing compounds through specific dye-polymer formulations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If existing sensors use luminescent sensing compounds to detect analytes, then single analyte detection is achieved, but multi-analyte detection capability is lost due to signal deconvolution challenges
Solution Approach 1:
The patent applies local quality by assigning different luminescent properties to different sensing compounds within the same sensor. Each compound is embedded in a polymer matrix that provides it with distinct temporal characteristics (lifetime and/or rise time), allowing signals from multiple analytes to be differentiated based on their unique temporal signatures rather than spatial separation.
Solution Approach 2:
The invention changes the temporal parameters of luminescent signals by using different polymer-sensing compound combinations. By adjusting polymer composition, crosslinking density, and other matrix parameters, the patent creates distinguishable lifetime and rise time values for each sensing compound, enabling multi-analyte detection through temporal parameter differentiation.
2Measurement precision
If a polymer scaffold is optimized for one luminescent sensing compound, then that compound's performance is improved, but compatibility with other sensing compounds is reduced
Solution Approach 1:
The patent creates a universal polymer scaffold system that can accommodate multiple types of luminescent sensing compounds simultaneously. By using a family of related polymers with varying properties (hydrophobicity, crosslinking density, glass transition temperature), the same basic scaffold architecture can be optimized for different sensing compounds while maintaining overall system compatibility and enabling multi-analyte detection.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables the simultaneous detection of multiple analytes with improved signal deconvolution capabilities, enhancing the accuracy and reliability of analyte monitoring by utilizing polymers that modify the emission duration and intensity of luminescent signals.
Implementation Method 1
luminescent sensing compounds configured to emit a luminescent signal that is dependent on a concentration and/or quantity of an analyte
Implementation Method 2
The sensor can include a first sensor portion and a second sensor portion, each composed of different polymer matrices, such that the sensor is capable of emitting, in response to a single excitation light, two analyte-dependent optical signals with the same emission wavelength, wherein the two analyte-dependent optical signals may be distinguished by their different lifetime characteristics
Data Source
AI summary
Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.