Multi-Carotenoid Composition for BPH Symptom Relief

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current treatments for aging-related urinary impairments and malfunctions in men, such as benign prostatic hyperplasia and lower urinary tract symptoms, often rely on drug therapies or major surgery, which come with risks and limitations, and there is a need for alternative, effective solutions.

Innovation Solution

The development of multi-carotenoids compositions for oral administration, comprising lycopene, phytoene, phytofluene, and a suitable carrier, processed into nutritional supplements or botanical drugs, which are encapsulated in soft-gel capsules or other forms, providing a synergistic effect to address urinary impairments.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If drug therapies (alpha-blockers and 5-alpha-reductase inhibitors) are used to treat BPH and LUTS, then urinary symptoms are improved, but the treatment requires lifelong administration and carries potential side effects

Engineering Contradiction:

Improvetreatment efficacyVSAvoidtreatment duration

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent employs a natural carotenoid-based composition as an alternative to conventional pharmaceutical drugs. This approach uses naturally occurring compounds (lycopene, phytoene, phytofluene) that can be administered through dietary supplements rather than requiring lifelong prescription medication, thereby reducing treatment duration and potential side effects while maintaining therapeutic benefits

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Reliability

If surgery is performed to treat prostate conditions, then symptoms are effectively relieved, but surgical risks and complications arise

Engineering Contradiction:

Improvetreatment efficacyVSAvoidsurgical risks

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent introduces carotenoid compositions as an intermediary therapeutic approach between conservative management and surgical intervention. These natural compounds act as mediators that can reduce prostate-related symptoms and slow disease progression without the harmful effects of surgery, providing a safer middle-ground treatment option

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent utilizes the antioxidant properties of carotenoids to counteract oxidative stress and inflammation in the prostate, converting the harmful effects of aging and metabolic processes into beneficial therapeutic effects that protect against prostate enlargement and symptom development

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

3Reliability

If single-carotenoid supplements are administered, then antioxidant effects are provided, but synergistic benefits are not fully realized

Engineering Contradiction:

Improveantioxidant effectVSAvoidtherapeutic versatility

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent employs a composite carotenoid composition containing multiple carotenoid compounds (lycopene, phytoene, phytofluene) in specific ratios. This composite approach leverages the synergistic interactions between different carotenoids to enhance antioxidant activity, anti-inflammatory effects, and overall therapeutic versatility compared to single-carotenoid supplements

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent combines multiple carotenoid compounds that occur naturally in tomatoes into a unified supplement formulation. This merging of compounds preserves their natural synergistic relationships and provides comprehensive health benefits that address multiple aspects of prostate health and urinary function simultaneously

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The multi-carotenoids compositions demonstrate significant increases in serum lycopene levels and reductions in PSA levels and IPSS scores, indicating potential improvements in urinary tract symptoms and quality of life for men with BPH and LUTS, suggesting a safe and effective alternative to existing treatments.

Implementation Method 1

The multi-carotenoids compositions demonstrate significant increases in serum lycopene levels

Methodology Applied

Scientific EffectAbsorption: Absorption (physical)

Data Source

PatentUS10561696B2Multi-carotenoids compositions and uses therefor

Publication Date: 2020.02.18 HEALTH EVER BIOTECH CO LTD

AI summary

Methods for ameliorating the effects of benign prostate hyperplasia (BPH)-related lower urinary tract symptoms (LUTS) in men, comprising orally administering an effective amount of multi-carotenoids compositions. Multi-carotenoids composition for oral administration comprising about 71% by weight, of a tomato extract containing therein about 2% to 10% by weight of lycopene, about 0.25% to 2% by weight of phytoene, and about 0.2% to 2% by weight of phytofluene, and about 29% by weight, of a suitable encapsulating matrix. A suitable encapsulating matrix is an edible oil exemplified by soya oil, pumpkin seed oil, grape-seed oil and the like. The tomato extract may additionally comprise one or more of at least one carotene selected from the group comprising β-carotene, γ-carotene, and δ-carotene, a phytosterol, a tocopheral and a phospholipid. Use of multi-carotenoids compositions for the treatment of urinary tract malfunctions including benign prostate hyperplasia and lower urinary tract symptoms.