Multi-Ceramide Skin Composition for Mitochondrial Energy Metabolism
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing treatments fail to comprehensively address the undesired changes in skin due to intrinsic and extrinsic aging, such as increased oxidative damage, inflammation, and loss of skin firmness, elasticity, and wrinkles, by effectively boosting skin cell energy metabolism.
Innovation Solution
A composition comprising compounds of formula I, including glucosyl ceramide, lactosyl ceramide, and ceramide NG, is topically applied to enhance mitochondrial function and ATP production in skin cells, upregulating key proteins of the respiratory chain to improve skin health and appearance.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional skin treatments are used, then basic skin maintenance is achieved, but they fail to comprehensively address aging-related changes such as oxidative damage, inflammation, and loss of skin firmness
Solution Approach 1:
The patent employs a composite formulation containing multiple ceramide types (glucosyl ceramide, lactosyl ceramide, and ceramide NG) working synergistically to address multiple aging mechanisms simultaneously, including oxidative damage, inflammation, and loss of skin firmness, thereby achieving comprehensive skin health improvement
2Power
If skin cell energy metabolism is not boosted, then energy requirements are met by conventional means, but mitochondrial function deteriorates leading to increased oxidative damage and reduced skin regeneration
Solution Approach 1:
The patent modifies mitochondrial function by introducing compounds that upregulate key respiratory chain proteins, thereby changing the metabolic parameters of skin cells to enhance ATP production and reduce oxidative damage, which directly improves skin regeneration capability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition improves skin complexion, radiance, tone, and reduces signs of aging, inflammation, and fatigue by enhancing mitochondrial energy metabolism, thereby supporting skin regeneration and reducing wrinkles.
Implementation Method 1
The energy requirements are met by mitochondrial respiration, an adenosine triphosphate (ATP) generating process driven by a series of protein complexes collectively known as electron transport chain (ETC) located on the inner membrane of the mitochondria
Implementation Method 2
The mammalian mitochondrial ETC is composed of transmembrane protein complex I (NADH dehydrogenase), complex II (succinate dehydrogenase), complex III (ubiquinol-cytochrome C oxidoreductase) and complex IV (cytochrome C oxidase)
Implementation Method 3
Natural by-products of respiration include reactive oxygen species (ROS), which play an important role in cell proliferation, hypoxia adaptation and cell fate determination, however excessive ROS can disrupt macromolecular and cellular structures if not quenched by the antioxidant system
Implementation Method 4
Complexes I and III are generally considered the main sites of ROS production where electron leaks and single electrons react with oxygen, producing superoxide anion
Data Source
AI summary
The present invention relates to a cosmetic use of a composition for boosting skin cell energy metabolism in an individual, wherein the composition comprises a compound of formula I, wherein the carbon-carbon bond noted Formula II is a double or a single bond, R1 is an alkyl chain having 10-20 carbon atoms, R2 is hydrogen or a substituted or unsubstituted acyl having 16-34 carbon atoms, R3 is hydrogen when the carbon-carbon bond noted is a double or a single bond, or R3 is —OH when the carbon-carbon bond noted is a single bond, R4 is hydrogen when the carbon-carbon bond noted is a double or a single bond, or R4 is hydrogen or —OH when the carbon-carbon bond noted is a double bond, X is hydrogen, a glucosyl moiety or a lactosyl moiety.