Multi-chamber Mixing Container Modular Aseptic Configuration
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Solution Overview
Problem
Existing multi-chamber mixing systems are inflexible, as they are typically prefabricated and lack the ability to vary the number of components or their arrangement, and often require integral needles and pistons for mixing, which are not suitable for all chemical or biological applications.
Innovation Solution
A multi-chamber mixing container system comprising a slip-on container, a removal container, and optionally intermediate containers, which can be individually combined and sealed aseptically, allowing for variable configuration and mixing without the need for needles or pistons, enabling the combination of specific active ingredients with solvents in desired concentrations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If multi-chamber mixing systems are prefabricated with integral components, then manufacturing consistency is improved, but adaptability and flexibility deteriorate
Solution Approach 1:
The mixing system is divided into separate, interchangeable chambers (e.g., solvent chamber, active ingredient chamber, intermediate chambers) that can be individually selected and combined. Each chamber is a standalone component with standardized interfaces, allowing different configurations for different applications while maintaining manufacturing consistency through standardized production of individual chambers.
Solution Approach 2:
The system employs universal chamber designs with standardized connections that can serve multiple functions. The same chamber types can be used across different mixing configurations, and the modular architecture allows a single chamber design to fulfill various roles depending on its position and contents in the mixing sequence.
2Ease of operation
If needles and pistons are used for mixing, then mixing capability is improved, but applicability to chemical and biological substances deteriorates
Solution Approach 1:
The design removes needles and pistons from the mixing mechanism. Instead, mixing is achieved by inverting the container, allowing gravity and pressure differential to drive the mixing process. This extraction of problematic components eliminates contamination risks and incompatibility issues with sensitive chemical and biological substances.
Solution Approach 2:
The mixing system is self-actuating through container inversion. The weight of the liquid and pressure differential automatically drive the mixing process without requiring external mechanical actuators like pistons. The system uses its own contents (the liquid pressure) to perform the mixing action.
3Productivity
If components are mixed in advance, then productivity is improved, but stability and efficacy of components deteriorate
Solution Approach 1:
Components are prepared in advance as separate, stable formulations in individual chambers. The active ingredients can be pre-lyophilized or pre-concentrated in their stable forms, and solvents are prepared separately. The mixing action is delayed until the moment of use through the inversion mechanism, combining the benefits of advance preparation with maintenance of stability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This system allows for the aseptic mixing of components under controlled conditions, ensuring sterility and flexibility in combining active ingredients with solvents, enhancing the stability and efficacy of pharmaceutical and industrial mixtures by enabling mixing just before use.
Implementation Method 1
The slip-on container and removal container are connected to one another in a sealed manner, in particular aseptically welded or glued to one another
Implementation Method 2
the component contained in the removal container can be dissolved in the liquid contained in the slip-on container or the two liquids can be mixed with one another
Data Source
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AI summary
The invention relates to a multi-chamber mixing container comprising an invertible container, a removable container and various optionally present intermediate containers, furthermore to a device for receiving and applying the multi-chamber mixing container and to methods for mixing liquids or liquids and solids under aseptic conditions in the multi-chamber mixing container.