Multi-Chambered Powder Dispensing for Consistent Inhaled Dosing
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Solution Overview
Problem
Existing dry powder inhaler devices are complex, costly, and inefficient, with inconsistent dose delivery due to reliance on external propellants or user inhalation, leading to contamination and poor patient compliance.
Innovation Solution
A multi-chambered dosage form with internal piercing devices and an external propellant source, allowing precise and efficient delivery of dry powder medicaments through integrated energetics, reducing device complexity and improving dose consistency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If external propellants or user inhalation are used to deliver dry powder medicaments, then powder delivery can be achieved, but device complexity and cost increase, and dose consistency deteriorates
Solution Approach 1:
The device is segmented into multiple independent chambers, each containing a specific amount of dry powder medicament. This segmentation allows for precise dosing control while simplifying the overall device structure, as each chamber operates independently without requiring complex external propellant systems.
Solution Approach 2:
The device utilizes the patient's own inhalation action to deliver the medicament, eliminating the need for external propellants or complex mechanical actuation systems. The patient's inhalation serves as the driving force, simplifying device complexity while maintaining dose consistency through proper chamber design.
2Productivity
If external propellants are used for powder delivery, then delivery efficiency can be improved, but device cost and complexity increase
Solution Approach 1:
The device harnesses the patient's natural inhalation flow to deliver the medicament, eliminating the need for external propellants. This self-service approach maintains delivery efficiency by utilizing the patient's own respiratory system as the propelling mechanism, while significantly reducing device complexity and cost.
Solution Approach 2:
The device utilizes pneumatic principles by leveraging the patient's inhalation-generated airflow to propel the dry powder medicament from the chamber. This approach achieves efficient powder delivery without requiring mechanical propellant systems, thereby reducing device complexity.
3Manufacturing precision
If multi-chambered design with internal piercing devices is used, then dose precision is improved, but manufacturing complexity increases
Solution Approach 1:
The device employs a multi-chambered design where each chamber is a separate, pre-filled unit containing a precise dose of medicament. This segmentation enables high dose precision while simplifying manufacturing, as each chamber can be independently filled and sealed using standard pharmaceutical packaging techniques, then assembled into the final device.
Solution Approach 2:
The chambers are pre-filled with precise doses of medicament during manufacturing, and the device is prepared in advance for use. This preliminary action ensures dose precision is achieved during manufacturing rather than during patient use, simplifying the overall manufacturing process while maintaining high precision.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances powder delivery efficiency, reduces device cost and complexity, and improves patient compliance by ensuring consistent and precise dosing without contamination.
Implementation Method 1
Upon pressurization of the blister, the lidstock controllably separates from the multi-chambered blister well base material such that a fluid communication path is opened
Data Source
AI summary
A multi-chambered dosage form assembly and device for expressing the dosage form are disclosed herein for the administration of a dry powder medicinal compound to a user. The present dosage form and device provides for improved patient ease of use, low cost, and consistent, contamination free dosing of dry powder medicaments or other agents to a user. Said methods, systems and devices provide increased powder ejection fraction and hence greater efficiency of drug delivery above that as provided by current devices.