Multi-component Injection System for Tissue Repair
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Solution Overview
Problem
Current medical injection technologies face challenges in maintaining the separation of components until they reach the target tissue, ensuring sterility of cell delivery, and controlling injection pressure to avoid further damage to compromised tissues during the delivery of cell-based therapies for tissue repair.
Innovation Solution
The development of an injection preparation device and kit that includes a multi-barrel syringe system with a body that reversibly engages multiple syringes, allowing for separate transfer and mixing of components, and an injection load monitoring device to control pressure, ensuring accurate and sterile delivery of a multi-component injection composition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If multiple components are combined in a single injection system, then the treatment effectiveness is improved, but the risk of premature polymerization increases
Solution Approach 1:
The injection system is divided into multiple separate barrels, each containing a different component (e.g., cells, carrier, crosslinking agent). These segmented components are kept separate during preparation and injection, only mixing at the target tissue site, thereby preventing premature polymerization while ensuring all necessary components are delivered for effective treatment.
Solution Approach 2:
A sterile transfer device acts as an intermediary between the non-sterile component storage and the sterile injection pathway. This intermediary maintains sterility during component transfer and enables controlled mixing at the injection site without premature reaction, resolving the conflict between component integration and polymerization control.
2Object-affected harmful factors
If components are kept separate until injection, then premature polymerization is prevented, but the device complexity increases
Solution Approach 1:
Multiple syringe barrels and transfer mechanisms are merged into a single integrated injection device. This consolidation allows the system to maintain separate components during preparation while providing a unified, relatively simple interface for the operator during injection, reducing the perceived complexity despite the multi-component nature of the system.
Solution Approach 2:
The injection device is designed with universal features that allow it to handle multiple components through a standardized mechanism. The same basic syringe and transfer structure is used for each component type, reducing overall device complexity by avoiding the need for specialized handling mechanisms for each component.
3Productivity
If injection pressure is increased to improve delivery speed, then treatment efficiency is improved, but tissue damage increases
Solution Approach 1:
The injection system employs dynamic pressure control, adjusting injection pressure in real-time based on resistance encountered. The system starts with lower pressure and increases only as needed to maintain adequate flow rate, preventing excessive pressure that would cause tissue damage while ensuring sufficient delivery speed for treatment efficiency.
Solution Approach 2:
The injection device incorporates feedback mechanisms that monitor injection resistance and adjust pressure accordingly. When resistance increases (indicating approaching target tissue or potential damage risk), the system automatically reduces pressure, maintaining optimal delivery speed while preventing tissue damage through continuous feedback control.
Data Source
AI summary
The present disclosure provides devices, kits and methods for preparing injections with cells and carrier components for delivery to a target area in the body. The disclosed devices, kits, and methods provide preparation and monitoring of injections.