Multi-container dialysate mixing system for bio-incompatible solutions
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Solution Overview
Problem
Current peritoneal dialysis solutions are bio-incompatible due to low pH, high glucose degradation products, and osmolality, leading to membrane damage and increased infection rates, with existing solutions being costly and unstable, limiting the effectiveness and duration of treatment.
Innovation Solution
A multi-container system for storing and mixing dialysate components separately, allowing for the creation of a stable bicarbonate-based dialysate with controlled pH and reduced glucose degradation, using containers with valves, clamps, and filters to ensure safe and efficient mixing and administration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If conventional single-container peritoneal dialysis solutions are used, then the system is simple to operate, but the solution becomes bio-incompatible due to low pH, high glucose degradation products, and osmolality
Solution Approach 1:
The patent divides the dialysate preparation into multiple separate containers, each holding different components (bicarbonate, glucose, electrolytes). These components are mixed only at the point of use, avoiding premature chemical reactions and degradation. This segmentation resolves the contradiction by maintaining solution stability while preserving operational simplicity through a modular mixing system.
Solution Approach 2:
The patent pre-prepares individual dialysate components in separate containers under controlled conditions, ensuring each component is stable and free from degradation. By performing the mixing action at the point of use rather than in advance, the system prevents glucose degradation and pH shifts that occur in conventional pre-mixed solutions, thereby resolving the bio-incompatibility issue.
2Productivity
If pre-sterilized single-container dialysis solutions are used, then the solution is ready for immediate use, but glucose degradation products accumulate leading to membrane damage
Solution Approach 1:
The patent separates glucose from other dialysate components into different containers. Glucose is stored independently in a sterile container without contact with bicarbonate or electrolytes until the moment of mixing. This prevents oxidative degradation and formation of harmful glucose degradation products while maintaining readiness for use through pre-sterilized separate components.
Solution Approach 2:
The patent introduces a controlled mixing mechanism that acts as an intermediary between the separate sterile components. The mixing system ensures that glucose only contacts other components under controlled conditions at the point of use, minimizing degradation while maintaining the convenience of ready-to-use pre-sterilized components.
3Object-affected harmful factors
If multi-container systems with separate components are used, then biocompatibility is improved, but the system complexity increases
Solution Approach 1:
The patent combines multiple separate dialysate components into a single mixed solution at the point of use. The mixing mechanism merges the sterile glucose solution with bicarbonate and electrolyte solutions, creating the final dialysate in one integrated step. This merging approach maintains biocompatibility through separate storage while reducing operational complexity by combining components at the point of use.
Solution Approach 2:
The patent designs a universal mixing system that can handle different dialysate formulations by simply changing the components in the separate containers. The same mixing mechanism works for various glucose concentrations, electrolyte compositions, and bicarbonate formulations, making the system adaptable without increasing complexity. This multi-functionality resolves the contradiction by maintaining biocompatibility while preserving operational simplicity.
4Reliability
If conventional dialysis solutions with high osmolality are used, then the dialysis effectiveness is maintained, but peritoneal membrane viability is reduced
Solution Approach 1:
The patent performs preliminary preparation of individual components under optimized conditions, including controlled pH and temperature for each separate container. By preparing bicarbonate, glucose, and electrolytes separately with proper pH control before mixing, the system achieves the required osmolality and dialysis effectiveness while preventing premature reactions that would generate harmful degradation products and damage the peritoneal membrane.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system provides a biocompatible, stable, and cost-effective dialysate solution that prolongs the viability of the peritoneal membrane, reduces infection rates, and extends the duration of peritoneal dialysis treatment by ensuring the dialysate remains effective and safe for patients.
Implementation Method 1
a filter in the second supply tube between the second locking connector and the third supply container
Data Source
AI summary
A multi-container system apparatus comprising at least two independent containers, each container of said at least two containers for containing at least one component of the final formulation of a medium; a connector; a connecting tubing line connected to the connector; at least two output tubing lines, the first and second output tubing lines of said at least two output tubing lines connecting the first and second containers of said at least two containers, respectively, to the connecting tubing line.