Multi-fluidic Cartridge with Pneumatic Pump for Point-of-Care Diagnostics
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Solution Overview
Problem
Current handheld diagnostic devices for biological samples are limited by the need for complex procedures and require trained technicians, with mono-fluidic cartridges restricting the complexity of tests that can be performed at the point of care.
Innovation Solution
Multi-fluidic cartridges with multiple rupturable fluidic pouches and pneumatic pumps allow for the controlled delivery of different fluids, such as reagents, wash fluids, and diluents, enabling more sophisticated sample analysis and testing protocols.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multi-fluidic cartridges with multiple rupturable pouches and pneumatic pumps are used, then test complexity and analysis capabilities are improved, but device complexity increases
Solution Approach 1:
The cartridge is divided into multiple independent fluidic pouches, each containing different reagents or fluids. This segmentation allows complex multi-step tests to be performed using simple individual pouches that can be independently activated, thereby increasing test complexity without proportionally increasing overall device complexity.
Solution Approach 2:
Multiple fluidic pouches are nested within a single cartridge housing, with each pouch containing smaller fluid compartments. This nesting arrangement allows multiple functions to be integrated into a compact structure, enabling complex testing capabilities while maintaining a manageable device form factor.
2Adaptability or versatility
If multiple different fluids are delivered to the conduit, then sample analysis capabilities are improved, but fluid transport complexity increases
Solution Approach 1:
A pneumatic pump system is used to transport multiple different fluids through the cartridge. The pump applies pneumatic pressure to sequentially or simultaneously deliver reagents, wash fluids, and diluents from their respective pouches through delivery conduits to the sample analysis chamber, simplifying the control of complex multi-fluid transport.
Solution Approach 2:
The pneumatic pump system serves multiple functions: it transports different fluids, controls fluid flow rates, and can be integrated with the cartridge actuation mechanism. This multi-functionality reduces the need for separate transport mechanisms for each fluid type, thereby managing fluid transport complexity while enhancing sample analysis capabilities.
3Measurement precision
If controlled delivery of different fluids is implemented, then test accuracy is improved, but mechanism complexity increases
Solution Approach 1:
Multiple fluidic pouches are pre-filled with specific reagents, wash fluids, and diluents in the correct quantities and concentrations. The cartridge is pre-assembled with delivery conduits positioned to ensure proper fluid mixing and flow paths. This preliminary preparation ensures accurate test results while minimizing the complexity of real-time control mechanisms during operation.
Solution Approach 2:
The cartridge design incorporates flow sensors and pressure sensors that provide feedback on fluid delivery status. This feedback mechanism ensures that the correct amount of each fluid is delivered to the sample, maintaining test accuracy while using simple binary feedback (fluid present/absent) rather than complex continuous control systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables advanced point-of-care testing with improved sample analysis capabilities, allowing for increased test complexity and accuracy without the need for extensive technical expertise, enhancing diagnostic timeliness and precision.
Implementation Method 1
at least one pneumatic pump configured to move the fluid sample to the one or more sensors
Implementation Method 2
transporting at least one of the different fluids to the first conduit
Data Source
AI summary
The invention is directed to multi-fluidic cartridges for sample analysis and to methods of using said cartridges. In one embodiment, the cartridge comprises: (a) a first conduit beginning at a sample entry port for receiving a fluid sample and in fluid communication with one or more sensors; (b) a plurality of rupturable fluidic pouches, each containing a different fluid and in fluid communication with a respective delivery conduit configured for delivering a respective fluid to said first conduit; and (c) at least one pneumatic pump configured to move said fluid sample to said one or more sensors and for transporting at least one of said different fluids to said first conduit.