Multi-Functional Adsorbing Material for Sepsis Blood Purification
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Solution Overview
Problem
Current adsorbing materials for sepsis treatment are limited in their ability to effectively adsorb multiple pathogenic factors, such as bacterial endotoxin, genomic DNA, peptidoglycan, lipoteichoic acid, virus RNA, and zymosan, which restricts their curative efficacy in treating sepsis induced by these factors.
Innovation Solution
Development of an adsorbing material formed by coupling a novel ligand with amino-functionalized agarose or polystyrene resin carriers, which is prepared through specific chemical reactions to achieve broad-spectrum adsorption of these pathogenic factors, enhancing the adsorption capacity in blood purification devices.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If conventional adsorbing materials (e.g., polymyxin B, lipid A monoclonal antibody) are used, then endotoxin adsorption is effective, but the materials cannot adsorb other pathogen-associated molecular patterns such as bacterial genomic DNA, peptidoglycan, lipoteichoic acid, virus RNA, and zymosan
Solution Approach 1:
The patent applies universality by designing a single adsorbing material with multi-functional ligands that can simultaneously recognize and bind to multiple different pathogen-associated molecular patterns. The ligand structure contains multiple functional groups (carboxyl, hydroxyl, amino) that can interact with various PAMPs including endotoxin, bacterial genomic DNA, peptidoglycan, lipoteichoic acid, virus RNA, and zymosan, making one material effective against diverse pathogens rather than requiring separate materials for each target.
Solution Approach 2:
The patent employs composite materials by combining a carrier (such as agarose or polystyrene resin) with a specially designed ligand that has multiple adsorption sites. The ligand itself is a composite structure containing different functional groups (carboxyl, hydroxyl, amino) that can bind to different types of pathogenic factors. This composite approach allows the material to maintain structural stability while achieving broad-spectrum adsorption capability.
2Adaptability or versatility
If multiple different adsorbing materials targeting different pathogenic factors are developed, then broader pathogen coverage is achieved, but the device complexity and treatment cost increase significantly
Solution Approach 1:
The patent resolves device complexity by creating a universal adsorbing material that replaces multiple specialized materials. Instead of requiring separate cartridges or columns for endotoxin, DNA, peptidoglycan, and other PAMPs, the invention provides a single material with multi-functional ligands that can handle all these targets simultaneously, simplifying the blood purification device architecture and reducing operational complexity.
Solution Approach 2:
The patent applies merging by consolidating multiple adsorption functions into a single integrated material. The ligand structure combines multiple binding capabilities (carboxyl groups for cationic PAMPs, hydroxyl groups for various interactions, amino groups for anionic PAMPs) into one unified adsorbing material, eliminating the need for multiple separate components and simplifying the overall system design.
3Adaptability or versatility
If a broad-spectrum ligand is designed to adsorb multiple pathogenic factors, then the adsorption capacity increases, but the manufacturing complexity and purification difficulty increase
Solution Approach 1:
The patent applies parameter changes by systematically varying the ligand structure to optimize both broad-spectrum adsorption and manufacturability. The ligand is designed with specific parameters (molecular weight, functional group ratios, spacer lengths) that balance adsorption capacity with synthesis feasibility. The carboxyl, hydroxyl, and amino groups are positioned and quantified to achieve optimal binding while maintaining reasonable synthetic complexity.
Solution Approach 2:
The patent uses segmentation by dividing the ligand into modular functional units (carboxyl-containing segments, hydroxyl-containing segments, amino-containing segments) that can be synthesized separately and then assembled. This modular approach simplifies the overall manufacturing process by breaking down the complex multi-functional ligand synthesis into manageable steps, each targeting a specific functional group or segment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adsorbing material significantly adsorbs bacterial endotoxin, genomic DNA, peptidoglycan, lipoteichoic acid, virus RNA, and zymosan, effectively reducing their levels in blood plasma and attenuating the inflammatory response, demonstrating improved treatment prospects for sepsis through blood purification.
Implementation Method 1
an adsorbing material with the effect of adsorbing pathogenic factors is the most core constituent part of the blood purification device
Data Source
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AI summary
An adsorbing material for multiple pathogenic factors of sepsis as well as a preparation method and an application thereof are provided. The adsorbing material is formed by coupling a carrier with good mechanical performance and blood compatibility and a ligand with the capacity to adsorb multiple pathogen-associated molecular patterns, and is capable of effectively adsorbing bacterial endotoxin, bacterial genomic DNA, peptidoglycan, lipoteichoic acid, virus RNA, and zymosan from fluids such as blood and the like, and in particular has application value in blood purification for treatment of sepsis.