Multi-Herb Pharmaceutical Composition for Muscle Atrophy Pathway Regulation
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Solution Overview
Problem
Current treatments for muscle atrophy, such as physical therapy, functional electrical stimulation, and anabolic steroids, are inadequate in reversing or curing the disease and are associated with significant side effects.
Innovation Solution
A pharmaceutical composition comprising an ethanol extract of Artemisia argyi, Morus alba L., Leonurus japonicus Houtt, Capsicum annuum L., Lophatherum gracile Brongn, Curcuma longa, and Glycyrrhiza uralensis, containing active ingredients like chlorogenic acid, leonurine, schaftoside, and curcumin, is administered to regulate atrophy pathogenic pathways and improve mitochondrial function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If anabolic steroids are administered to treat muscle atrophy, then muscle strength and protein synthesis are improved, but serious side effects occur including kidney problems, liver damage, heart problems, cancer, and hormone changes
Solution Approach 1:
The patent replaces long-term anabolic steroid therapy with a herbal composition containing multiple natural ingredients (Artemisia argyi, Morus alba, Leonurus japonicus, Capsicum annuum, Lophatherum gracile, Curcuma longa, and Glycyrrhiza uralensis) that can be administered without the serious side effects associated with steroids, offering a safer alternative for muscle atrophy treatment
Solution Approach 2:
The invention uses a composite herbal formulation combining seven different plant ingredients, each contributing specific active compounds (such as chlorogenic acid, curcumin, and glycyrrhizic acid) that work synergistically to treat muscle atrophy without the harmful effects of single-agent anabolic steroids
2Strength
If physical therapy and functional electrical stimulation are used to treat muscle atrophy, then muscle strength and circulation are improved, but the progression of muscle loss is only slowed down without reversal or cure
Solution Approach 1:
The patent changes the therapeutic approach from physical intervention (physical therapy and electrical stimulation) to pharmacological intervention with a herbal composition that actively reverses muscle atrophy by regulating molecular pathways, achieving both strength improvement and disease reversal
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively treats muscle atrophy by down-regulating atrophy-associated molecules and enhancing mitochondrial function, providing a therapeutic benefit without the side effects of anabolic steroids.
Implementation Method 1
the ethanol extract is obtained via extracting Artemisia argyi, Morus alba L., Leonurus japonicus Houtt, Capsicum annuum L., Lophatherum gracile Brongn, Curcuma longa, and Glycyrrhiza uralensis by ethanol at about 30-100° C. for about 0.5-5 hours
Data Source
AI summary
Disclosed herein are pharmaceutical compositions and uses thereof in treating muscle atrophy. The pharmaceutical composition comprises an ethanol extract of an herbal mixture consisting of Artemisia argyi, Morus alba L., Leonurus japonicus Houtt, Capsicum annuum L., Lophatherum gracile Brongn, Curcuma longa, and Glycyrrhiza uralensis; and a pharmaceutically acceptable excipient. The ethanol extract comprise 14 ingredients, including chlorogenic acid, leonurine, schaftoside, rutin, isochaftoside, isochlorogenic acid, 4, 5-dicaffeoylquinic acid, quercetin, apigenin, glycyrrhizic acid, bisdemethoxycurcumin, demethoxycurcumin, curcumin and artemisetin.