Multi-Ionic Complex to Widen Lithium's Anti-Inflammatory Window

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Solution Overview

Problem

Existing treatments for inflammation, particularly neurogenic inflammation, face challenges such as toxicity issues with lithium and the need to widen the therapeutic window, while deregulation of magnesium, lithium, and potassium ions contributes to chronic and acute inflammation in various pathologies.

Innovation Solution

A synergistic multi-ionic complex comprising specific molar ratios of lithium, magnesium, and potassium salts, designed to restore cellular homeostasis and inhibit pro-inflammatory pathways, reducing lithium toxicity and promoting anti-inflammatory effects.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If lithium is used to treat inflammation, then anti-inflammatory effects are improved, but toxicity increases

Engineering Contradiction:

Improveanti-inflammatory efficacyVSAvoidlithium toxicity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines lithium with magnesium and potassium in a multi-ionic complex, merging their therapeutic effects while using magnesium and potassium to mitigate lithium's toxicity. This combination approach allows achieving anti-inflammatory efficacy while reducing harmful effects through synergistic interaction of multiple ions.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

Magnesium and potassium act as intermediary substances that modulate lithium's biological activity. They serve as protective agents that enable lithium's anti-inflammatory effects while reducing its toxicity, effectively mediating between the beneficial and harmful properties of lithium.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If lithium concentration is increased to enhance anti-inflammatory effects, then therapeutic window is narrowed, but toxicity increases

Engineering Contradiction:

Improvetherapeutic effectVSAvoidtoxicity threshold

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the parameter of lithium administration from pure lithium salt to a multi-ionic complex with specific molar ratios. This parameter change allows achieving higher effective concentrations of lithium for therapeutic effect while the accompanying magnesium and potassium prevent toxicity, effectively widening the therapeutic window.

Inventive Principle:

Principle #35Parameter changes

3Object-generated harmful factors

If magnesium, lithium, and potassium ions are deregulated, then cellular homeostasis is disrupted, but inflammation increases

Engineering Contradiction:

ImproveinflammationVSAvoidcellular homeostasis

Core Design Contradiction:

Object-generated harmful factorsVSStability of the object's composition

Solution Approach 1:

The multi-ionic complex restores cellular homeostasis of magnesium, lithium, and potassium ions before inflammation can fully develop. By re-establishing proper ionic balance in advance, the complex prevents the deregulation that would otherwise lead to chronic inflammation and related pathologies.

Inventive Principle:

Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The multi-ionic complex effectively prevents and treats inflammation by restoring cellular homeostasis, reducing toxicity, and enhancing cellular resistance to insults, particularly in neurogenic inflammation.

Implementation Method 1

a depletion of intracellular magnesium Mg2+ follows, with concentrations that can drop by 40 to 60% in the case of damage

Methodology Applied

Scientific EffectIon homeostasis:

Implementation Method 2

Lithium and magnesium possess similar ionic rays (0.60 and 0.65 Angström, respectively) and similar physicochemical properties allowing them to compete successfully to bind to several magnesium-dependent enzyme sites

Methodology Applied

Scientific EffectIonic competition:

Implementation Method 3

These ionic rays allow lithium and magnesium to easily cross cell membranes

Methodology Applied

Scientific EffectIon transport:

Implementation Method 4

The NLRP3 inflammasome promotes caspase-l-dependent release of pro-inflammatory cytokines IL-1β and IL-18

Methodology Applied

Scientific EffectAnti-inflammatory action:

Data Source

PatentUS20250345362A1Multi-ionic complex for the prevention or treatment of inflammation

Publication Date: 2025.11.13 YNIOS PHARMA

AI summary

The invention relates to a synergistic multi-ionic complex providing potentiated preventive and therapeutic responses to inflammation by modulating the pathways of immunity. It is a composition comprising mineral salts, including at least one mineral salt of lithium, magnesium and potassium, characterized by the following molar ratios: lithium 1-magnesium [0.13-0.34]-potassium [1.20-2.40]. The composition according to the invention may also contain organic salts, other mineral salts, additives and/or excipients. It can be used as a drug, medical device for the prevention and/or treatment of inflammation, associated with acute or chronic pathologies involving cell degeneration.