Multi-Lamellar Emulsion Composition for Skin Application
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Solution Overview
Problem
Existing multi-lamellar emulsion compositions for skin external application face challenges in maintaining stability with high amounts of dermatologically useful oleophilic substances, as conventional formulations struggle to form stable structures with lipid components like long-chain amide, sterol, fatty acid, and fatty alcohol beyond 4 wt%.
Innovation Solution
A multi-lamellar emulsion composition with 15-22 wt% lipid components, 3-4 wt% long-chain amide and sterol, 12-18 wt% fatty acid and fatty alcohol, 6-10 wt% emulsifier, and balanced purified water, with specific ratios of long-chain amide to sterol (0.1-1.8:1) and lipid components to emulsifier (1.8-3.0:1) to ensure phase stability and applicability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If the content of emulsifier is increased to emulsify larger amounts of oil, then the emulsification efficiency is improved, but skin irritation is caused
Solution Approach 1:
The patent changes the chemical composition parameters by introducing specific lipid components (long-chain amide, sterol, fatty acid, fatty alcohol) with defined ratios to replace traditional high-emulsifier formulations, achieving stable emulsification with reduced emulsifier content and minimized skin irritation
Solution Approach 2:
The patent creates a composite emulsion system combining multiple lipid components (long-chain amide, sterol, fatty acid, fatty alcohol) with emulsifier and thickener in specific proportions to achieve synergistic effects that improve emulsification efficiency while reducing skin irritation compared to single-component systems
2Stability of the object's composition
If the content of thickener is increased to maintain emulsion stability, then the formulation stability is improved, but the ability to contain large amounts of oil is reduced
Solution Approach 1:
The patent optimizes the thickener content parameter to a specific range (0.5-5 wt%) and compensates by adjusting lipid component ratios and introducing multi-lamellar structures, achieving both high oil content (15-40 wt%) and stable formulation without excessive thickener
3Ease of manufacture
If the content of lipid components is increased to 15 wt% or more for easier processing and storage, then the ease of manufacture and storage is improved, but the formation of stable multi-lamellar structure becomes difficult
Solution Approach 1:
The patent defines specific parameter ranges for lipid components (15-22 wt% total, with long-chain amide 3-4 wt%, sterol 3-4 wt%, fatty acid 12-18 wt%, fatty alcohol 12-18 wt%) and their ratios (long-chain amide to sterol 0.1-1.8:1, lipid to emulsifier 1.8-3.0:1) to enable stable multi-lamellar structure formation at high lipid content
Solution Approach 2:
The patent creates a composite lipid system combining long-chain amide, sterol, fatty acid, and fatty alcohol in specific proportions that synergistically promote multi-lamellar structure formation and stability at high total lipid content (15-22 wt%), making the formulation easier to process and store while maintaining structural integrity
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves high phase stability, excellent properties, and good skin feel, enabling the use of large amounts of dermatologically useful substances while maintaining stability over time.
Implementation Method 1
emulsion layers formed between the oil phase and the water phase are self-assembled by the geometrical structure of components thereof and the interaction between functional groups present in the molecules
Implementation Method 2
The lipid components discussed herein have weak amphiphilic properties and are considered to have properties intermediate between the properties of surfactants and the properties of oil
Implementation Method 3
the content of an emulsifier functioning to prevent the separation between oil and water for a certain period of time is increased so that an increased amount of oil will be emulsified
Data Source
AI summary
The composition of external application to the skin according to the present invention may specifically control the relative amount between long-chain amides and sterols and the relative amount between lipid components and an emulsifier in the emulsion having a multi-layered lamella structure, the emulsion comprising a relatively larger content of dermatologically useful hydrophobic material in a formulation. Thus, the formulation having significantly high stability and excellent characteristics can be obtained in spite of the high content in the lipid components and the emulsifier.